Analysis of syncopal DRVR in blood donors: multicenter hemovigilance data (2020—2023)

Junhong YANG; Qing XU; Wenqin ZHU; Fei TANG; Ruru HE; Zhenping LU; Zhujiang YE; Fade ZHONG; Gang WU; Guoqiang FENG; Xiaojie GUO; Jia ZENG; Xia HUANG

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Analysis of syncopal DRVR in blood donors: multicenter hemovigilance data (2020—2023)

VernacularTitle:2020—2023年献血者晕厥性血管迷走神经反应多中心监测结果分析
Author: Junhong YANG ¹ ; Qing XU ² ; Wenqin ZHU ³ ; Fei TANG ⁴ ; Ruru HE ⁵ ; Zhenping LU ⁶ ; Zhujiang YE ⁷ ; Fade ZHONG ⁸ ; Gang WU ⁹ ; Guoqiang FENG ¹⁰ ; Xiaojie GUO ² ; Jia ZENG ³ ; Xia HUANG ¹
Author Information

1. Chongqing Blood Center, Chongqing 400052, China
2. Anhui Blood Center, Hefei 230000, China
3. Fujian Blood Center, Fuzhou 350004, China
4. Guizhou Blood Center, Guiyang 550002, China
5. Nanning Central Blood Station, Nanning 530000, China
6. Ganzhou Central Blood Station, Ganzhou 341000, China
7. Dongguan Central Blood Station, Dongguan 523016, China
8. Ningbo Central Blood Station, Ningbo 315010, China
9. Qinghai Blood Center, Xining 810000, China
10. Shanxi Blood Center, Taiyuan 030024, China
Publication Type:Journal Article
Keywords: donor hemovigilance; blood donation adverse reaction; donation related vasovagal reaction; syncope; severity; multicentre monitoring
From: Chinese Journal of Blood Transfusion 2025;38(8):1071-1076
CountryChina
Language:Chinese
Abstract: Objective: Data on syncopal donation-related vasovagal reaction (DRVR) collected from 74 blood centers between 2020 and 2023 was statistically analyzed to provide a reference for developing preventive strategies against syncopal DRVR. Methods: Data on blood donation adverse reactions and basic information of donors from 2020 to 2023 were collected through the information management system at monitoring sentinel sites. Statistical analysis was performed on the following aspects of syncopal DRVR: characteristics of donors who experienced syncope, reported incidence, triggers, duration, presence and occurrence time of syncope-related trauma, clinical management including outpatient and inpatient treatment, and severity grading. Results: From 2020 to 2023, 45 966 donation-related adverse reactions were recorded. Of these, 1 665 (3.72%) cases were syncopal DRVR. The incidence of syncopal DRVR decreased with age, being the highest in the 18-22 age group. Incidence was significantly higher in female donors than male donors, in first-time donors than repeat donors, and in university and individual donors than group donors (all P<0.05). There was no statistically significant difference among different blood donation locations (P>0.05). The top three triggers were tension, fatigue, and needle phobia or fear of blood. Among syncopal DRVR cases, 60.36% occurred during blood collection, 87.63% lasted for less than 60 seconds, and 5.05% were accompanied by trauma. Notably, 57.14% of these traumas occurred after donor had left the blood collection site. Syncope severity was graded based on required treatment: grade 1 (fully recovered without treatment, 95.50%); grade 2 (recovered after outpatient treatment, 4.02%); and grade 3 (recovered after inpatient treatment, 0.48%). Conclusion: By analyzing the data of syncopal DRVR cases, it is possible to provide a reference for formulating blood donor safety policies.