Functional transformation of microglia and advances in targeted therapy in age-related macular degeneration
10.3980/j.issn.1672-5123.2025.9.12
- VernacularTitle:小胶质细胞在年龄相关性黄斑变性中的功能转化及靶向治疗进展
- Author:
Chen HE
1
;
Wei LI
1
;
Xiaoyan DOU
1
;
Haojiang YANG
1
Author Information
1. Department of Ophthalmology, the First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Guangdong Province, China
- Publication Type:Journal Article
- Keywords:
age-related macular degeneration;
microglia;
senescence;
mechanism;
treatment
- From:
International Eye Science
2025;25(9):1455-1459
- CountryChina
- Language:Chinese
-
Abstract:
Age-related macular degeneration(AMD)is a prevalent retinal degenerative disease closely linked to age and stands as a leading cause of central vision loss among the elderly. Under physiological condition, microglia in the retina plays crucial roles in tissue homeostasis, immune surveillance, and tissue repair. However, in pathological state, microglia can be abnormally activated and migrate to AMD lesion sites, which results in exacerbating damage to retinal pigment epithelial cells and photoreceptor cells, thus promoting the progression of AMD. This review focuses on the origins, distribution, and functional changes of microglia under physiological and pathological conditions. Recent advances in microglia-targeted therapies for AMD are also summarized, which provides a theoretical basis for the development of novel treatment strategies.
