Research progress on the treatment role and chemical synthesis methods of isoselenoazolones

VernacularTitle:异硒唑酮类化合物在疾病治疗中的作用和化学合成方法
Author: Wentao WANG ^{1
,

2} ; Xing GAO ^{1
,

2} ; Fengping ZHAO ^{1
,

2} ; Canhui ZHENG ² ; Xin CHEN ³
Author Information

1. School of Life Science and Technology,Wuhan Polytechnic University, Wuhan 430023，China
2. School of Pharmacy, Naval Medical University, Shanghai 200433，China.
3. School of Life Science and Technology,Wuhan Polytechnic University, Wuhan 430023，China.
Publication Type:Reviews
Keywords: organoselenium compounds; isoselenoazolones; ebselen; glutathione peroxidase; mimics
From: Journal of Pharmaceutical Practice and Service 2025;43(8):367-372
CountryChina
Language:Chinese
Abstract: Glutathione peroxidase （GSH-Px） is a key selenoenzyme that protects the body from oxidative damage. A series of small molecular organic selenium compounds have been designed and synthesized as functional mimics of GPx, among which isoselenazolones are the most widely studied. Taking ebselen as a representative, the catalytic mechanism of isoselenazolones in mimicing GSH-Px activity in vivo, the therapeutic effects of isoselenazolones in stroke, sensorineurium deafness and tinnitus, treatmentresistant depression （TRD） and coronavirus disease 2019 （COVID-19）, and research on their chemical synthesis methods were summarized and discussed in this paper.