Investigation of latent tuberculosis infection among the elderly in rural areas of Changxing County， Zhejiang Province
10.19428/j.cnki.sjpm.2025.24635
- VernacularTitle:浙江省长兴县农村老年人结核分枝杆菌潜伏感染调查
- Author:
Jian ZHANG
1
;
Yufang SONG
1
;
Feilin REN
2
;
Xuejing LI
1
;
Jiasheng QIN
1
;
Bin SHAO
3
Author Information
1. Changxing County Center for Disease Control and Prevention, Changxing, Zhejiang 313100, China
2. Huzhou City Center for Disease Control and Prevention, Huzhou, Zhejiang 313000, China
3. Changxing County Health Bureau, Changxing, Zhejiang 313100, China
- Publication Type:Journal Article
- Keywords:
Mycobacterium tuberculosis;
latent tuberculosis infection;
rural elderly;
interferon-γ release assay
- From:
Shanghai Journal of Preventive Medicine
2025;37(6):503-506
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the current status of latent tuberculosis infection (LTBI) among the elderly population in rural areas of Changxing County, Zhejiang Province, and to provide an evidence for the development of LTBI prevention and control measures. MethodsBetween January and May 2024, elderly individuals participating in urban and rural residents’ health checkups were screened for Mycobacterium tuberculosis infection using a domestically produced interferon-γ release assay (IGRA) kit. Individuals tested positive by IGRA but without active tuberculosis were classified as LTBI cases. The prevalence of LTBI among the participants was subsequently analyzed. ResultsAmong the 6 765 subjects, 637 tested positive by IGRA, including one identified active tuberculosis patient, resulting in a LTBI prevalence rate of 9.40%. There was a statistically significant difference in positivity rates across different IGRA methodologies (χ2=35.530, P<0.001). Higher LTBI rate was observed in males, individuals with a history of diabetes mellitus, and those with a history of pulmonary tuberculosis, exhibiting statistically significant differences (χ2=32.401, P<0.001; χ2=5.789, P=0.020; χ2=39.248, P<0.001, respectively.) No statistically significant difference in LTBI rate was found across different age groups (χ2=0.238, P=0.971). ConclusionThe prevalence of LTBI among the elderly rural residents in Changxing County is relatively low. Male, individuals with a history of diabetes mellitus, and those with a history of pulmonary tuberculosis have an increased risk of LTBI, warranting targeted risk monitoring and timely interventions.
