Effect Mechanism and Law of Sterilization by 60Co-γ Ray Irradiation on Chemical Composition of Chinese Materia Medica： A Review
10.13422/j.cnki.syfjx.20251066
- VernacularTitle:60Co-γ射线辐照灭菌对中药化学成分影响的机制及规律研究进展
- Author:
Tingting ZHU
1
;
Jian RANG
2
;
Rangyanpo LUO
2
;
Rui GU
3
;
Yue YANG
1
;
Si LU
1
;
Shihong ZHONG
1
Author Information
1. School of Pharmacy，Southwest Minzu University，Chengdu 610200，China
2. Institute of Tibetan Medicine of Aba Tibetan and Qiang Autonomous Prefecture，Maerkang 624099，China
3. College of Ethnomedicine，Chengdu University of Traditional Chinese Medicine，Chengdu 611173，China
- Publication Type:Journal Article
- Keywords:
60Co-γ ray;
irradiation sterilization;
Chinese materia medica;
compositional variation;
mechanism;
patterns;
irradiation dose
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(18):306-314
- CountryChina
- Language:Chinese
-
Abstract:
60Co-γ ray irradiation has the unique advantages of high efficiency， strong penetration， operation at room temperature and no residue， which has been widely used in the sterilization of Chinese medicinal materials， decoction pieces， Chinese patent medicine. However， the irradiation effect may cause changes in the content of chemical components in Chinese materia medica or the emergence of new radiolysis products， leading to reduced efficacy and uncontrollable safety risks. This paper reviewed the relevant literature at home and abroad， summarized the effect of irradiation sterilization on various types of chemical compositions of Chinese medicinal materials and their preparations， and analyzed and explored the rule of change. The results showed that the content changes of various chemical components in Chinese materia medica after 60Co-γ ray irradiation sterilization varied. The contents of most flavonoids， terpenoids， phenylpropanoids and quinones decreased after irradiation， and the degree of decrease increased with the elevated irradiation dose. The contents of lignans， alkaloids， isoflavones and some terpenoids did not change significantly before and after irradiation， while the content changes of triterpenoid saponins， dihydroflavonols， chalcones， sugars and glycosides after irradiation were not yet uniform. Therefore， it is recommended to pay attention to the compositional changes of irradiated Chinese medicines， strengthen the research on the standards of irradiated Chinese medicines， and standardize the irradiation and sterilization of Chinese medicines in order to promote the healthy and rational application of irradiated Chinese medicines.
