Analysis of Animal Models of Autoimmune Thyroiditis Based on Clinical Characteristics of Traditional Chinese and Western Medicine
10.13422/j.cnki.syfjx.20250218
- VernacularTitle:基于中西医临床病证特点的自身免疫性甲状腺炎动物模型分析
- Author:
Sifeng JIA
1
;
Zhuo ZHANG
1
;
Yuyu DUAN
1
;
Keqiu YAN
1
;
Xinhe ZUO
1
;
Yang LI
2
;
Yong ZHAO
1
Author Information
1. Hubei University of Chinese Medicine， Wuhan 430061， China
2. Hubei University of Chinese Medicine Affiliated Hubei Provincial Traditional Chinese Medicine Hospital， Wuhan 430061， China
- Publication Type:Journal Article
- Keywords:
autoimmune thyroiditis;
animal model;
combination of traditional Chinese and western medicine;
clinical consistency
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(18):235-243
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveAutoimmune thyroiditis （AIT） is a complex and immune-mediated disorder， with no established treatment protocol. Both Western and traditional Chinese medicine （TCM） focus on the pathogenesis and treatment of AIT. This study evaluated the clinical consistency of existing AIT animal models based on the diagnostic criteria of both Western and TCM， using a novel evaluation method. Additionally， it proposed recommendations and future prospects for improving these models. MethodsA comprehensive literature review was conducted on existing AIT animal models， using databases and the diagnostic criteria of both Western and TCM. Core and accompanying symptoms of these models were scored based on the diagnostic criteria of both Western and TCM， and clinical consistency was assessed. ResultsMice are the primary experimental animals used in AIT modeling. Modeling methods include vaccine immunization， iodine induction， heterologous thyroid antigen immunization， and a combination of high iodine water and antigen immunization. The average consistency of clinical syndromes based on TCM and Western medicine is 40%， 60%， 54%， and 63%， with the highest consistency observed in the combined high iodine water and antigen immunization model. Pathological models based on TCM are less common， with the liver-stagnation-spleen-deficiency rat model showing high clinical consistency. While most models are designed according to Western medical theory， meeting the surface and structural effectiveness criteria of Western medicine. However， there is a lack of fine-tuning and clear differentiation of TCM syndromes. ConclusionCurrent AIT syndrome-disease combination animal models primarily reflect the pathological features of Western medicine， with limited integration of TCM syndromes. Future research should aim to combine the syndrome characteristics of TCM with the pathological features of Western medicine， creating multi-factor and dynamic syndrome-disease models. Such models would better facilitate an experimental platform that conforms to the theories of TCM， providing more comprehensive support and guidance for the pathogenesis and treatment strategies of AIT.
