Textual Research and Ancient and Modern Application of Classical Prescription Sinisan
10.13422/j.cnki.syfjx.20241015
- VernacularTitle:经典名方四逆散关键信息考证与古今应用分析
- Author:
Lyuyuan LIANG
1
;
Qing TANG
1
;
Jialei CAO
2
;
Wenxi WEI
3
;
Yuxin ZHANG
2
;
Jinyu CHEN
2
;
Hejia WAN
3
;
Chen CHEN
2
;
Ruiting SU
1
;
Bingqi WEI
4
;
Shen'ao DING
2
;
Bingxiang MA
1
;
Wenli SHI
1
Author Information
1. Pediatric Hospital， The First Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450099，China
2. School of Pediatrics， Henan University of Chinese Medicine， Zhengzhou 450046，China
3. School of Medicine， Henan University of Chinese Medicine， Zhengzhou 450046，China
4. Henan Liang Jishi Research Institute of Chinese Medicine，Zhengzhou 450000，China
- Publication Type:Journal Article
- Keywords:
Sinisan;
ancient and modern literature;
key information;
textual research;
clinical application
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(18):182-193
- CountryChina
- Language:Chinese
-
Abstract:
Sinisan is a classical prescription developed and applied by ancient medical experts and it is first recorded in the Treatise on Cold Damage written by ZHANG Zhongjing in the Eastern Han Dynasty. Later physicians have modified this prescription based on this original one. The bibliometrics methods were used to analyze the key information and research trend of Sinisan. According to the inclusion and exclusion criteria， 69 pieces of effective data were extracted， involving 67 ancient traditional Chinese medicine （TCM） books. The results showed that the name， composition， and decocting methods of Sinisan in later generations were inherited from the original record in the Treatise on Cold Damage. The original plants of medicinal materials used in Sinisan are basically clear. We recommend Bupleuri Radix as the dried root of Bupleurem scorzonerifolium， Paeoniae Radix Alba as the dried root of Paeonia lactiflora， Aurantii Fructus as the dried fruit of Citrus aurantium， Glycyrrhizae Radix et Rhizoma as the dry root and rhizome of Glycyrrhiza uralensis. Raw materials of Bupleuri Radix and Paeoniae Radix Alba， Aurantii Fructus stir-fried with bran， and stir-fried Glycyrrhizae Radix et Rhizoma should be used for preparation of Sinisan. According to measurement system in the Han Dynasty， a bag of Sinisan is composed of 1.25 g Bupleuri Radix， 1.25 g Paeoniae Radix Alba， 1.25 g Aurantii Fructus， and 1.25 g Glycyrrhizae Radix et Rhizoma. The materials should be grounded into coarse powder and taken with a proper amount of rice soup， 3 times a day. Sinisan has the effects of regulating qi movement and harmonizing the liver and spleen. It can be used for treating reversal cold in limbs and cold damage. In modern clinical practice， Sinisan can be used to treat chronic gastritis， irritable bowel syndrome， and dyspepsia. The above research results provide scientific reference for the future research and development of Sinisan.
