Research progress on female reproductive toxicity of bisphenols

Jia PENG; Xiangzhu YAN; Jiasi LIU; Xiaopeng ZHONG; Simin YAO; Yiyan MA; Shuhua TAN

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Research progress on female reproductive toxicity of bisphenols

VernacularTitle:双酚类物质雌性生殖毒性研究进展
Author: Jia PENG ¹ ; Xiangzhu YAN ^{2
,

3} ; Jiasi LIU ¹ ; Xiaopeng ZHONG ¹ ; Simin YAO ¹ ; Yiyan MA ¹ ; Shuhua TAN ^{2
,

4}
Author Information

1. School of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan, Hunan 411201, China.
2. School of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan, Hunan 411201, China
3. Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, Hunan 410205, China.
4. Key Laboratory of Ecological Remediation and Safe Utilization of Heavy Metal Polluted Soils College of Hunan Province, Xiangtan, Hunan 411201, China.
Publication Type:Review
Keywords: bisphenols; female reproductive system; endocrine disruption; reproductive toxicity
From: Journal of Environmental and Occupational Medicine 2025;42(7):862-869
CountryChina
Language:Chinese
Abstract: Bisphenols (BPs) are extensively used in food packaging, personal care products, and plastics, making them prevalent in both living and working environments, which has raised significant concern. As endocrine-disrupting chemicals, BPs exert toxic effects on the female reproductive system by binding to estrogen receptors, thereby activating or inhibiting the expression of genes related to reproductive functions, which disrupts the normal function of the endocrine system. This paper reviewed the effects of bisphenol A (BPA), bisphenol S (BPS), and bisphenol F (BPF) on female reproductive function, focusing on three key aspects: the effects on the female reproductive organs, the occurrence of associated reproductive disorders, and the mechanisms of toxicity. Specifically, this review highlighted the effects on ovarian function, uterine morphology and function, and fallopian tube function, as well as their correlation with polycystic ovary syndrome, endometriosis, miscarriage, and eclampsia. Additionally, the toxic mechanisms of BPs exposure were summarized, providing a scientific basis for future research on the impact of BPs on the female reproductive system, as well as for the assessment of potential health risks and the development of preventive measures.