Construction of drug utilization evaluation criteria for Dezocine injection based on evidence-based methodology and Delphi method
- VernacularTitle:基于循证方法学和德尔菲法构建地佐辛注射液的药物利用评价标准
- Author:
Yuanyuan GUO
1
;
Chao WANG
1
;
Yinpeng QIN
1
;
Yi ZHANG
1
;
Yishan BU
1
Author Information
1. Dept. of Pharmacy，Tianjin First Central Hospital，Tianjin 300192，China
- Publication Type:Journal Article
- Keywords:
Dezocine injection;
drug utilization;
evaluation criteria;
evidence-based methodology;
Delphi method
- From:
China Pharmacy
2025;36(15):1841-1845
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To construct the drug utilization evaluation criteria for Dezocine injection， so as to provide reference for the rational drug use in medical institutions. METHODS On the basis of evidence methodology， relevant guidelines/expert consensus， systematic reviews/meta-analysis were consulted； the evaluation criteria framework for Dezocine injection was established after screening evidence. Delphi method was employed， whereby 28 clinicians and clinical pharmacists from secondary and above-level medical institutions across eight provinces， including Tianjin， Beijing and Shandong， were selected to participate in two rounds of questionnaire surveys. The final indicators were determined based on the experts’ enthusiasm coefficient， authority coefficient， and degree of coordination. RESULTS The effective recovery rate of questionnaire was 100% in the first round and 92.86% in the second round； expert authority coefficient was 0.82 in the first round and 0.81 in the second round； the coordination degree of experts in the first round was 0.29， and in the second round was 0.31 （P＜0.001）. Drug utilization evaluation standard system for Dezocine injection was formed finally， including three dimensions of medication indications， medication process and medication results， with a total of 11 first-level indicators （such as indications， usage and dosage） and 33 second-level indicators （such as labor analgesia and the management of severe pain following major or moderate surgeries combined with other analgesic drugs）. The average importance scores for each indicator ranged from 4.08 to 5.00 points， with an overall average score of 4.61 points and coefficient of variation ranging from 0 to 0.19. CONCLUSIONS The drug utilization evaluation criteria for Dezocine injection established based on evidence-based methodology and Delphi method is authoritative and scientific， which provides a reference for subsequent evaluation of the rationality of clinical medication.
