The philosophical basis of nursing research is simply about increasing our knowledge and addressing everyday challenges through reflective thinking. This article explored the fundamental principles that inform nursing research and stresses nurse researchers' vital role in meeting everyday challenges. By employing classic philosophical concepts and contemporary ways of knowing, this article explained how individual beliefs, conceptions about truth, and reflections on self had contributed to knowledge development. To put it plainly, this article is about the story of a nurse researcher and the illustration of how a nurse's philosophy impacts research and consequently contributes to the development of nursing science. Instead of regarding this process as a quest for the ultimate truth, this article recognized the evolving process of interacting with fluid knowledge to advance nursing practice and do well in society.