Nasal-to-Brain Drug Delivery Strategies for Active Ingredients of Traditional Chinese Medicine：A Review
10.13422/j.cnki.syfjx.20251262
- VernacularTitle:中药有效成分经鼻入脑递药策略的研究进展
- Author:
Yang CHEN
1
;
Tiantian WANG
1
;
Yufang HUANG
1
;
Guangdi YANG
2
;
Shengmou HU
1
;
Xiaomeng LEI
1
;
Wenliu ZHANG
1
;
Dongxun LI
1
;
Canjian WANG
1
;
Guosong ZHANG
1
Author Information
1. Jiangxi University of Chinese Medicine，Nanchang 330006，China
2. Guangxi University of Chinese Medicine，Nanning 530200，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
nasal drug delivery;
central nervous system diseases;
blood-brain barrier;
drug delivery system;
guide medicine upwards;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(17):252-261
- CountryChina
- Language:Chinese
-
Abstract:
Central nervous system（CNS） disorders are characterized by complex pathological mechanisms and the presence of the blood-brain barrier（BBB）， which significantly limits the effectiveness of drug therapy. Traditional drug delivery modes include oral administration， intravenous injection and transdermal delivery， which have certain advantages， but it is difficult for the drugs to effectively cross the BBB. Therefore， it is crucial to find drug delivery modes that can efficiently traverse the BBB. Nasal drug delivery， as a non-invasive method， can realize the targeted delivery of drugs to the CNS via three pathways， including olfactory neurons， trigeminal neurons and blood circulation， and shows a broad application prospect in the treatment of CNS diseases. Numerous studies have further confirmed that nasal drug delivery combined with novel drug delivery systems such as lipid nanocarriers， nanoparticles， nanoemulsions and composite in situ gels can effectively load the active components of traditional Chinese medicine（TCM）， and significantly increase drug concentration in the brain， which provides new strategies for the treatment of CNS diseases. In this paper， the current status of drug delivery for CNS diseases was systematically sorted out， the characteristics of nasal drug delivery were discussed in depth， and the research progress of passive targeting， active targeting， and "guiding the meridian" drug delivery strategies for the nasal-to-brain transport of TCM active components was summarized and analyzed， which was aimed to provide references and insights for the development of drugs for CNS diseases and the application of TCM in nasal-to-brain delivery.
