Analysis of Animal Models of Primary Dysmenorrhea Based on Clinical Features in Traditional Chinese and Western Medicine
10.13422/j.cnki.syfjx.20251003
- VernacularTitle:基于中西医临床病证特点的原发性痛经动物模型分析
- Author:
Qinghua WANG
1
;
Yu HUAN
1
;
Shuangling ZHOU
1
;
Ting ZUO
1
;
Mingsan MIAO
1
Author Information
1. School of Pharmacy， Henan University of Chinese Medicine， Zhengzhou 450046， China
- Publication Type:Journal Article
- Keywords:
primary dysmenorrhea;
disease characteristics;
diagnostic criteria;
concordance rate;
model analysis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(17):220-226
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo systematically review the modeling methods and analyzes the model alignment with clinical features of primary dysmenorrhea （PD） in both traditional Chinese medicine （TCM） and western medicine， providing theoretical and practical guidance for establishing the animal models of PD that better reflect the diagnostic and therapeutic characteristics of both TCM and western medicine. MethodsThe literature on PD animal models was searched against domestic and international databases such as PubMed， CNKI， and Wanfang Data. According to the diagnostic criteria of TCM and western medicine， the modeling methods in the literature were summarized， evaluated for strengths and weaknesses， and systematically assessed for clinical concordance rates to identify suitable reference models. ResultsThe available animal models of PD showed the average clinical concordance rates of 43.64% and 61.27% with the clinical features in TCM and western medicine， respectively. Commonly used modeling methods included estrogen administration， physical stimulation， and surgical intervention， with the estrogen combined with oxytocin model and the ice-water bath model being the most studied. The model of Qi stagnation and blood stasis syndrome that was established with the comprehensive stimulation method demonstrated the highest clinical concordance rate. ConclusionCurrent PD animal models primarily replicate dysmenorrhea and simulate menstruation， but they differ from human menstruation to some extent and cannot fully reflect the pathogenesis and physiological characteristics of PD. Moreover， except the cold coagulation and dampness stagnation syndrome and Qi stagnation and blood stasis syndrome， no animal models for other TCM syndromes have been reported， which limits comprehensive TCM research on this disease to a certain extent.
