Traditional Chinese Medicine Compound Formulas in Treatment of Ulcerative Colitis by Regulating NLRP3 Inflammasome Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20241211
- VernacularTitle:中药复方调控NLRP3炎症小体相关信号通路治疗溃疡性结肠炎研究进展
- Author:
Guanyu ZHAO
1
;
Ruihua XIN
2
;
Ying WANG
1
;
Lei SHI
1
;
Lidong DU
1
;
Guotai WU
1
Author Information
1. College of Pharmacy， Gansu University of Chinese Medicine， Lanzhou 730000， China
2. Lanzhou Institute of Husbandry and Pharmaceutical Sciences， Chinese Academy of Agricultural Sciences， Lanzhou 730050， China
- Publication Type:Journal Article
- Keywords:
Chinese medicine compound formula;
Nod-like receptor pyrin domain-containing 3（NLRP3） inflammasome;
signaling pathway;
ulcerative colitis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(17):305-314
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis （UC） is a refractory disease of the digestive system characterized by diverse etiologies， complex pathogenesis， a prolonged course， and frequent relapses. In recent years， the incidence of UC has been increasing annually， severely impairing patients' quality of life， posing a risk of malignant transformation that may threaten patients' lives， and resulting in a substantial medical burden. Traditional Chinese medicine （TCM） compound formulas， with their advantages of multi-component and multi-target actions， have become a new therapeutic option for UC. The NOD-like receptor pyrin domain-containing 3 （NLRP3） inflammasome is a core component of innate immunity， and its aberrant activation is closely associated with the onset and progression of UC， involving multiple processes such as inflammation and oxidative stress， and exhibiting crosstalk with pathways including nuclear factor-κB （NF-κB）， nuclear factor erythroid 2-related factor 2 （Nrf2）， and thioredoxin-interacting protein （TXNIP）. At present， NLRP3 has become one of the most intensely studied hotspots in UC-related research. Although increasing studies have focused on the regulation of the NLRP3 inflammasome by TCM compound formulas for UC treatment， challenges remain due to the complex pathogenesis of UC and the compositional diversity of TCM， hindering the realization of precision therapy. In this context， by reviewing literature from the past decade， this paper summarizes the activation process of NLRP3 and its relationship with UC， and elucidates the roles and mechanisms by which TCM compound formulas regulate the NLRP3 inflammasome and related signaling pathways， with a view to providing a reference for further research into the pathogenesis of UC， TCM treatment strategies， and their mechanisms of action.
