Traditional Chinese Medicine in Regulating Endoplasmic Reticulum Stress for Treatment of Ulcerative Colitis： A Review
10.13422/j.cnki.syfjx.20250893
- VernacularTitle:中医药调控内质网应激治疗溃疡性结肠炎的研究进展
- Author:
Keqiu YAN
1
;
Xiaoyu ZHANG
2
;
Guangjun SUN
2
;
Aizhen LIN
1
Author Information
1. Hubei University of Chinese Medicine，Wuhan 430065，China
2. Hubei Provincial Hospital of Traditional Chinese Medicine，Wuhan 430061，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
ulcerative colitis;
endoplasmic reticulum stress;
apoptosis;
autophagy
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(17):285-294
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis （UC） is a chronic and relapsing inflammatory bowel disease that primarily affects the mucosal layer of the rectum and colon. Its pathogenesis is complex and remains incompletely understood. Endoplasmic reticulum stress （ERS） plays a critical role in cellular responses to external stress and the maintenance of homeostasis， and its abnormal activation is closely associated with the development of various inflammatory diseases， particularly in the pathological process of UC. ERS maintains cellular homeostasis by activating the unfolded protein response （UPR）. However， when ERS is prolonged or excessive， UPR fails to alleviate the stress， leading to epithelial cell death and aggravating the progression of UC. Modulating ERS may serve as a key target for the prevention and treatment of UC， and it is one of the current research hotspots. Traditional Chinese medicine （TCM） has shown significant efficacy in regulating ERS， offering unique therapeutic advantages through multi-target and multi-pathway mechanisms. Recent studies have confirmed that TCM can alleviate ERS， inhibit apoptosis， regulate autophagy， reduce inflammatory responses， and maintain intestinal barrier function to prevent and treat UC. This review summarized the relationship between ERS and UC and discussed the intervention of TCM in regulating ERS for the treatment of UC， aiming to provide new insights and approaches for the treatment of UC with TCM.
