Prevention and Treatment of Asthma by Traditional Chinese Medicine Regulating PI3K/Akt Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20250662
- VernacularTitle:中医药调控PI3K/Akt信号通路干预哮喘的研究进展
- Author:
Yasheng DENG
1
;
Yanping FAN
1
;
Wenyue LI
1
;
Yonghui LIU
1
;
Zhaobing NI
1
;
Jinjiang XU
1
;
Haobin CHEN
1
;
Qiuye WU
1
;
Jiang LIN
1
Author Information
1. Guangxi University of Chinese Medicine，Nanning 530200，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine（TCM）;
asthma;
phosphatidylinositol 3-kinase/protein kinase B（PI3K/Akt） signaling pathway;
airway inflammation;
airway remodeling;
potential targets;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(17):262-275
- CountryChina
- Language:Chinese
-
Abstract:
Asthma is a chronic inflammatory respiratory disease involving multiple cells and cellular components， characterized by recurrent episodes of wheezing， shortness of breath， chest tightness， and coughing， significantly impacting patients' quality of life. The phosphatidylinositol 3-kinase/protein kinase B（PI3K/Akt） signaling pathway， as a crucial hub in intracellular signaling， is widely involved in the regulation of cell growth， proliferation， survival， metabolism， and a series of pathophysiological processes. Its regulatory role in the pathological progression of asthma is particularly significant， specifically in promoting airway inflammation， mediating epithelial mesenchymal transition， accelerating airway remodeling， regulating cell autophagy， inducing mucus hypersecretion， and influencing immune response balance. This study analyzed potential molecular targets of the PI3K/Akt pathway， including activators such as cysteine proteinase inhibitor 1（CST1）， found in inflammatory zone 1（FIZZ1） and free fatty acid receptor 1（FFAR1）， and inhibitors such as human β-defensin-3（hBD-3）， disintegrins， metalloproteinase 33（ADAM33） and interleukin-27（IL-27）， and initially revealed the potential molecular mechanisms of traditional Chinese medicine（TCM） in asthma intervention. Based on this， the authors systematically summarized the efficacy and specific mechanisms of TCM monomers， compounds， and external treatments for asthma by regulating the PI3K/Akt signaling pathway through literature review and analysis， aiming at establishing a robust foundation for the wide application and advanced development of TCM in asthma treatment， offering innovative insights for clinical research and drug development of asthma.
