Treatment of Rheumatoid Arthritis with Flavonoids in Traditional Chinese Medicine: A Review
10.13422/j.cnki.syfjx.20250338
- VernacularTitle:中药黄酮类化合物治疗类风湿性关节炎的研究进展
- Author:
Mingjie FAN
1
;
Longfei LIN
1
;
Ruying TANG
1
;
Zhuo XU
1
;
Qian LIAO
1
;
Hui LI
1
;
Yuling LIU
1
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
- Publication Type:Review
- Keywords:
flavonoid compound;
rheumatoid arthritis;
mechanism of action;
signaling pathway;
fibroblast-like synoviocyte
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(17):244-251
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovitis as its pathological basis. Although current therapeutic drugs can alleviate symptoms, they are often accompanied by a high risk of side effects. In recent years, the use of flavonoids from traditional Chinese medicine (TCM) in the treatment of RA has garnered significant attention. Studies have shown that the mechanisms by which flavonoids treat RA include inhibiting the release of pro-inflammatory factors, regulating multiple cellular signaling pathways, alleviating oxidative stress, modulating immune system functions, inhibiting bone destruction, and suppressing angiogenesis. Due to their notable anti-inflammatory, antioxidant, and immunomodulatory activities, flavonoids hold promise as potential therapeutic agents for RA. A substantial number of articles in this field have been published. By reviewing Chinese and international literature and applying bibliometric and visual analysis using CiteSpace, this paper explored research hotspots and frontiers in this field, systematically reviewed the structures and anti-RA mechanisms of TCM flavonoids, provided a theoretical basis for their use in RA treatment and clinical applications, and offered new perspectives and references for the discovery of novel TCM-based anti-RA drugs.