The association of Fibrosis-4 (FIB 4) index with chronic kidney disease among type 2 diabetes mellitus patients with concomitant non-alcoholic fatty liver disease: A single center cross-sectional study.
- Author:
Antonio O. PESCADOR JR.
1
;
Gabriel V. JASUL JR.
1
;
Oliver Allan C. DAMPIL
1
;
Juliet L. GOPEZ-CERVANTES
1
;
Luz Margaret A. ESCUETA
1
Author Information
- Publication Type:Journal Article, Original
- Keywords: Fibrosis-4 Index; Fib-4
- MeSH: Human; Diabetes Mellitus; Non-alcoholic Fatty Liver Disease; Chronic Kidney Diseases; Renal Insufficiency, Chronic
- From: Philippine Journal of Internal Medicine 2025;63(2):138-145
- CountryPhilippines
- Language:English
-
Abstract:
BACKGROUND
Non-alcoholic fatty liver disease (NAFLD) is prevalent in patients with Type 2 Diabetes Mellitus (T2DM) and is associated with chronic kidney disease (CKD). The aim of this cross-sectional study was to determine the association of Fibrosis-4 (FIB-4) index with CKD among T2DM patients with concomitant NAFLD.
METHODOLOGYA single center, analytical cross-sectional study was conducted among 216 T2DM patients with concomitant NAFLD. Clinical data were obtained via retrospective review of medical charts. The outcome of interest was CKD which was based on self-report obtained from medical charts or estimated Glomerular Filtration Rate (eGFR)RESULTS
Higher FIB-4 index was found to be significantly associated with CKD. Patients with FIB-4 index of 1.45-3.25 (moderate risk) and >3.25 (high risk) have about 3 times higher odds of CKD. However, after controlling for the significant confounders, only those who belong to high-risk group was found to be associated with CKD.
CONCLUSIONThis study has demonstrated that FIB4 index > 3.25, an index of liver fibrosis, is significantly associated with development of CKD in T2DM patients with concomitant NAFLD.
