Discussion on the Core Pathogenesis and Prevention and Treatment Strategy for Postoperative Recurrence of Colorectal Cancer from the Spatiotemporal Evolution of the Cancer Toxin Theory
10.13288/j.11-2166/r.2025.15.005
- VernacularTitle:从癌毒病机时空演变探讨肠癌术后复发核心病机及防治策略
- Author:
Xuechen GENG
1
;
Liu LI
1
;
Qinchang ZHANG
1
;
Qianqian BU
1
;
Haibo CHENG
1
Author Information
1. The First Clinical College of Nanjing University of Chinese Medicine，Nanjing，210023
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
cancer toxin;
recurrence;
spleen qi depletion;
damp-heat stasis toxin
- From:
Journal of Traditional Chinese Medicine
2025;66(15):1538-1542
- CountryChina
- Language:Chinese
-
Abstract:
According to the theory of cancer toxin pathogenesis， tumors are complex syndromes centered on cancer toxin， characterized by multiple time points and locations， interwoven pathogenic toxins， and a combination of deficiency and excess. Postoperative recurrence of colorectal cancer is a dynamic spatiotemporal process. In this paper， the core pathogenesis of postoperative recurrence of colorectal cancer， namely "deficiency of spleen qi， with damp-heat stasis toxin"， has been discussed based on spatiotemporal evolution of cancer toxin. It is suggested that spleen qi depletion leading to the proliferation of cancer toxin represents the temporal characteristic of postoperative recurrence， while the stasis of damp-heat facilitating the aggregation and spread of cancer toxin refelct its spatial pattern. This paper has constructed a holistic spatiotemporal prevention and treatment strategy according to different stages before and after recurrence. Before recurrence， the focus is on prevention， and it is suggested to rectify the healthy qi and fortify spleen， clear heat and resolve dampness， unblock collaterals and remove toxin. After recurrence， the focus should be on treatment， and the strategy is combating cancer and removing toxin， breaking the blood to eliminate disease， regulating and tonifying the zang-fu （脏腑） organs.
