Research progress on salivary gland mucosa-associated lymphoid tissue lymphoma
10.12016/j.issn.2096-1456.202550105
- Author:
DONG Jiaqi
1
;
ZHAO Huiting
2
;
LUO Guanfa
1
;
YANG Xihu
1
Author Information
1. Department of Stomatology, Affiliated Hospital of Jiangsu University
2. 1.Department of Stomatology, Affiliated Hospital of Jiangsu University 2School of Stomatology, Jinzhou Medical University.
- Publication Type:Review
- Keywords:
salivary gland mucosa-associated lymphoid tissue lymphoma;
mucosa-associated lymphoid tissue lymphoma;
salivary gland malignant tumor;
lymphoepithelial sialadenitis;
Sjögren's syndrome;
lymphoma;
pathogenesis
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2025;33(9):809-818
- CountryChina
- Language:Chinese
-
Abstract:
Salivary gland mucosa-associated lymphoid tissue lymphoma (SGML) is a subvariety of marginal zone B-cells that occurs outside of mucosal lymph nodes. The onset of SGML is closely related to immunity, chronic infections, and genetic factors, such as lymphoepithelial sialadenitis (LESA) and Sjogren’s syndrome (SS), as well as Helicobacter pylori, hepatitis C virus, Epstein-Barr virus, and human T-lymphocytic virus. The most common site of SGML is the parotid gland, followed by the submandibular gland, small salivary gland, and sublingual gland. SGML is more common in middle-aged and elderly women, and patients often have autoimmune diseases, such as Sjogren’s syndrome or rheumatoid arthritis. SGML can be diagnosed through clinical manifestations, imaging, and histopathology, but histopathological biopsy remains the main method for confirming SGML. Traditional treatment methods include anti-infective therapy and surgery combined with radiation or chemotherapy. In recent years, some new treatment methods, such as Bruton tyrosine kinase (BTK) inhibitors and programmed cell death protein-1 (PD-1) inhibitors, have been effective against recurrent or refractory SGML, but more clinical trial data are needed to support them. At present, the optimal treatment for SGML is not yet clear. Individualized treatment plans should be developed based on the location, staging, clinical characteristics, and overall health status of the patient. SGML progresses slowly and has a relatively good overall prognosis; however, the disease is recurrent, the treatment cycle is long, the recurrence rate is higher than that of other mucosa-associated lymphoid tissue lymphomas, and SGML may also cause other serious complications. Therefore, regular observation and follow-up are very important for its prognosis. This article reviews the etiology, diagnosis, treatment, and prognosis of SGML, with the aim of providing a reference for clinical diagnosis and treatment, and thus improve the survival rate of patients with SGML.
- Full text:2025090514432089519唾液腺黏膜相关淋巴组织淋巴瘤的研究进展.pdf
