Engineering of mesenchymal stem cell-derived exosomes and their application progress in the field of oral medicine
10.12016/j.issn.2096-1456.202440339
- Author:
ZHAO Yunfeng
1
;
LIU Qian
2
;
LI Meng
3
;
LI Luying
2
;
ZHANG Wei
2
;
HU Xiantong
4
;
MA Chufan
2
Author Information
1. 1.Department of Stomatology, Air Force Medical University Air Force Medical Center 2China Medical University.
2. Department of Stomatology, Air Force Medical University Air Force Medical Center
3. 1.Department of Stomatology, Air Force Medical University Air Force Medical Center 2.Anhui Medical University
4. The Fourth Medical Center of the General Hospital of CPLA
- Publication Type:Review
- Keywords:
mesenchymal stem cell;
engineered exosomes;
exosome modification;
stomatology;
dental pulp regeneration;
periodontal regeneration;
bone regeneration;
oral cancer;
tissue regeneration
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2025;33(9):792-800
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, mesenchymal stem cell-derived exosomes (MSC-EXO) have garnered increasing attention in the field of stomatology and have become an established research area in biomedical research. This article reviews the engineering of exosomes derived from mesenchymal stem cells and their application in the field of stomatology, in order to provide new ideas for the development of stomatology. Exosomes are nanoscale membrane vesicles secreted by cells and contain a variety of proteins, RNAs, lipids, and other biomolecules. They are transported through the circulatory system and can interact with other cells to regulate their biological behavior and participate in a variety of physiological and pathological processes. In the treatment of oral diseases, exosomes have shown great potential due to their natural biological activity and versatility. However, studies have found that relying solely on the function of natural exosomes may not fully meet the complex clinical requirements. Therefore, the concept of engineered exosomes has emerged. Engineered exosomes can be modified by bioengineering technology to enhance their targeting, allowing them to reach the lesion site more accurately. At the same time, engineered exosomes can also be surface modified or loaded internally to carry specific therapeutic molecules, such as drugs, gene editing tools or signaling molecules to improve the therapeutic effect. In addition, this engineered treatment can also confer greater stability to exosomes, making them better able to resist clearance by the immune system when circulating in the body, extending their half-life, and improving the effectiveness of treatment. Although engineered exosomes have attracted extensive attention in the fields of stomatology and other fields, their application is still mainly in the stage of basic research. To promote the clinical application of engineered exosomes, it is necessary to provide more sufficient evidence of biocompatibility and clarify their therapeutic effect and mechanism.
- Full text:2025090514333980212间充质干细胞来源外泌体的工程化及其在口腔医学领域的应用进展.pdf
