Source analysis of epileptiform discharges in idiopathic epilepsy with centrotemporal spikes： A study based on magnetoencephalography
10.19845/j.cnki.zfysjjbzz.2025.0138
- VernacularTitle:特发性伴中央颞区棘波癫痫谱系疾病患者的癫痫放电源的脑磁图分析研究
- Author:
Yiran DUAN
1
;
Yongbo ZHANG
1
;
Yuping WANG
2
Author Information
1. 首都医科大学附属北京友谊医院神经内科，北京 100050
2. 首都医科大学宣武医院神经内科，北京 100053
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Spectrum disease;
Magnetoencephalography;
Spike source
- MeSH:
Magnetoencephalography
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(8):722-726
- CountryChina
- Language:Chinese
-
Abstract:
Objective Idiopathic rolandic epilepsy syndrome （IRES） is the most common epilepsy syndrome in childhood， and its lesion site remains undetermined. This article aims to investigate the source of epileptiform discharges in IRES using magnetoencephalography （MEG）.Methods A total of 70 patients with IRES were enrolled in this prospective MEG-based study， among whom there were 53 children with benign epilepsy of childhood with centrotemporal spikes （BECTS）， 12 children with atypical benign partial epilepsy （ABPE）， 3 children with Landau-Kleffner syndrome （LKS）， and 2 children with epileptic encephalopathy with continuous spike-and-waves during slow-wave sleep （CSWS）. Epileptiform discharges were collected independently from each patient 10 times， and an MEG source analysis was performed. Standardized low-resolution brain electromagnetic tomography was used to perform source localization of the distributed source model. The spike source density was quantified into amplitude， and source location was determined according to the Desikan-Killiany atlas. The association between the distribution of spike source in brain and clinical manifestations was analyzed.Results In IRES， there were significant differences in the source locations of epilepsy discharge between BECTS， ABPE， LKS， and CSWS. The current source density of CSWS was stronger in the frontal lobe， the temporal lobe， and the anterior cingulate gyrus， while that of ABPE was stronger in the frontal lobe， and that of BECTS and LKS were stronger in the temporal lobe. The more severe phenotype of epilepsy， such as generalized tonic-clonic seizure， was associated with a stronger current source density in the brain， which was consistent with electroencephalography manifestations.Conclusion This study identifies different sources of epileptiform discharges in IRES. The density distribution of these spike sources may help to explain the discharge， cognitive， and neuropsychological characteristics in different subtypes of IRES.
- Full text:2025090413430730498特发性伴中央颞区棘波癫痫谱系疾病患者的癫痫放电源的脑磁图分析研究.pdf
