Comparison of intravenous single dose Lidocaine and single dose Propofol in controlling emergence agitation in children for surgery under sevoflurane anesthesia: a randomized controlled trial
- Author:
Jelleen E. Narvaza
1
;
Richard Andre A. Lucero
1
Author Information
- Publication Type:Journal Article
- Keywords: emergence agitation; PAED scale; FLACC scale
- MeSH: propofol; lidocaine
- From: The Philippine Children’s Medical Center Journal 2025;21(1):86-103
- CountryPhilippines
- Language:English
-
Abstract:
OBJECTIVE:To determine the efficacy and safety of intravenous single dose lidocaine versus single dose propofol in controlling emergence agitation in children aged 2-6 years old for surgery under sevoflurane anesthesia in Philippine Children’s Medical Center.
MATERIALS AND METHODS:This was a double-blind, randomized controlled trial of 64 children aged 2-6 years who had surgery under general anesthesia using sevoflurane. Patients were randomly assigned into 2 equal groups – the experimental (Lidocaine, L) group and the control (Propofol, P) group. Five (5) minutes prior to the discontinuation of sevoflurane, the patient assigned to the L group was given Lidocaine at 1.5 mg/kg IV while the patient assigned to the P group was given Propofol 1 mg/kg IV. Patients were monitored using Pediatric Anesthesia Emergence Delirium (PAED) and Face, Legs, Activity, Cry, and Consolability (FLACC) scales 5 minutes after giving the medication until discharge from the PACU. Data was collected using a data abstraction form.
RESULTS:There were no statistically significant differences between the 2 groups in terms of emergence agitation (RR= 0.5, 95% CI [0.098, 2.54], pvalue= 0.672) and post- operative pain (RR:0.6, 95% CI [0.033, 1.91], pvalue = 0.426). No adverse events were observed in both groups.
CONCLUSION:Both Lidocaine and Propofol are effective in preventing emergence agitation. - Full text:2025090316484794251pcmc 21(1) Article 6.pdf
