ROLE OF LACTOFERRIN ON THE HISTOPATHOLOGICAL CHANGES OF HYPERLIPIDEMIC-INDUCED FATTY LIVER IN RATS
https://doi.org/10.22452/jummec.vol26no2.22
- Author:
Valencia Chandra
1
;
Louis Fabio Jonathan Jusni
1
;
Tena Djuartina
2
;
Dion Notario
3
;
Zita Arieselia
4
;
Linawati Hananta
4
Author Information
1. School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Jakarta Indonesia.
2. Department of Anatomy, School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Jakarta Indonesia.
3. Department of Pharmacy, School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Jakarta Indonesia.
4. Department of Pharmacology, School of Medicine and Health Science, Atma Jaya Catholic University of Indonesia, Jakarta Indonesia.
- Publication Type:Journal Article
- Keywords:
Histology;
Hyperlipidemia;
Lactoferrin;
Liver;
Sprague-Dawley Rats
- MeSH:
Histology
- From:Journal of University of Malaya Medical Centre
2023;26(2):160-163
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Hyperlipidemia is a condition that may lead to many illnesses. The worldwide prevalence of hyperlipidemia is still relatively high. Lactoferrin is a glycoprotein found in mammals and fishes’ epithelial mucosa cells, also known for its protective roles.
Objective: This study aims to d
Objective:This study aims to discover the histopathologic changes in rat’s liver after the intervention of 100, 200, and 400 mg/kgBW lactoferrin.
Method:This study involved 30 Sprague-Dawley rats divided into six groups: normal, negative control, statin-treated, dose 1, dose 2, and dose 3. The normal group was given standard feed, while the other groups were hyperlipidemic induced by a high cholesterol diet. The intervention for the statin-treated group was 1.5 mg/kgBW statin, while dose 1, 2, and 3 were respectively given 100 mg/kgBW, 200 mg/kgBW, and 400 mg/kgBW of lactoferrin. After six weeks, all rats were dissected, and the livers’ histopathologic slides were scored with Manja Roenigk scoring.
Result:Lactoferrin improved the fatty liver condition. The statistical test results showed that 200 mg/kgBW of lactoferrin caused a significant change in the rats’ liver structures (p < 0.05).
Conclusion:200 mg/kgBW of lactoferrin significantly improved the histopathologic structure of fatty liver
- Full text:2025082112074012478118992.pdf
