CASE REPORT - Delayed hypersensitivity reaction to allopurinol: A case report
https://doi.org/10.51866/cr.65
- Author:
Mohammad Che Man
1
;
Shahidah Che Alhadi
2
;
Wan Fatimah Suriyani Wan Mahmud
3
;
Salman Amiruddin
4
;
Mohd Zhafri Mohd Razib
5
;
Rasimah Ismail
6
Author Information
1. MD (UKM), MMED (USM) Department of Family Medicine, Kulliyyah of Medicine, International Islamic University Malaysia, Indera Mahkota Campus, Kuantan,Pahang, Malaysia.
2. MBBS (IIUM), MMED (Surgery) (USM) Department of Surgery, Kulliyyah of Medicine, International Islamic University Malaysia, Indera Mahkota Campus, Kuantan, Pahang, Malaysia
3. MD (UKM) Department of Family Medicine, Kulliyyah of Medicine, International Islamic University Malaysia, Indera Mahkota Campus,Kuantan, Pahang, Malaysia.
4. MBBCh (University of Cairo), MS (ORL-HNS) (UKM) Fakulti Perubatan, Universiti Sultan Zainal Abidin (UniSZA), Kuala Terengganu, Terengganu, Malaysia.
5. MBBS (IIUM), Master of Family Medicine (IIUM) Department of Family Medicine, Kulliyyah of Medicine, International Islamic University Malaysia, Indera Mahkota Campus, Kuantan, Pahang, Malaysia.
6. MBBS (University of Wales College of Medicine), Doctor of Internal Medicine (UKM), AdvMDerm (UKM) Department of Internal Medicine (Dermatology), Kulliyyah of Medicine, International Islamic University Malaysia, Indera Mahkota Campus, Kuantan, Pahang, Malaysia.
- Publication Type:Journal Article
- Keywords:
Delayed hypersensitivity;
Allopurinol;
Rashes;
Xanthine oxidase inhibitor
- MeSH:
Hypersensitivity, Delayed;
Allopurinol;
Exanthema
- From:Malaysian Family Physician
2023;18(All Issues):1-3
- CountryMalaysia
- Language:English
-
Abstract:
Allopurinol is the well-known first-line treatment option for symptomatic hyperuricaemia and gout. It is cost-effective particularly for the management of chronic gout. The common early side effects of allopurinol are skin rashes, diarrhoea and nausea. Meanwhile, a dangerous concerning complication is Stevens–Johnson syndrome, which can cause severe morbidity and mortality. Delayed hypersensitivity to allopurinol is rare but should be one of the differential diagnoses if a patient with underlying gout on chronic allopurinol treatment presents with skin rashes. The present case highlights the importance of a high index of suspicion in at-risk patients with underlying gout along with skin rashes on long-term allopurinol treatment to avoid unnecessary patient management.
- Full text:202508210939063406218.11CRDelayedhypersensitivity.pdf
