HEART FAILURE WITH PRESERVED EJECTION FRACTION AND OBESITY: A REVIEW
https://doi.org/10.22452/jummec.sp2022no1.17
- Author:
Nur Alya Syamimie Muzaidi
1
,
2
;
Soo Huat Teoh
1
,
2
;
Mastura Mohd Sopian
1
,
2
Author Information
1. Department of Clinical Medicine, Institut Perubatan &
2. Pergigian Termaju, Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang, Malaysia
- Publication Type:Journal Article
- Keywords:
Heart failure with preserved ejection fraction;
Obesity;
HFpEF;
Heart failure
- MeSH:
Heart Failure, Diastolic
- From:Journal of University of Malaya Medical Centre
2022;25(SPECIAL ISSUE):148-151
- CountryMalaysia
- Language:English
-
Abstract:
Heart Failure with Preserved Ejection Fraction (HFpEF) is becoming more common as the United States (U.S.A) population ages, along with the present of obesity pandemic. In general, HFpEF is the most common type of heart failure (HF) found in general population, however, the elderly, especially women are mostly suffering from it. It is primarily caused by obesity, hypertension, coronary artery disease, and diabetes. Obesity is frequent in individuals with HFpEF. However, it may constitute a distinct phenotype of HFpEF, with distinct hemodynamic and anatomical problems. Obesity causes a systemic inflammatory response which can lead to cardiac fibrosis and endothelial dysfunction. Because most obese patients are still excluded from HFpEF clinical trials, further research is needed to evaluate the role of pharmacologic and interventional treatments in this expanding group. Thus, this review study will aid in the understanding of HFpEF and its association with obesity.
- Full text:2025082009385298725107559.pdf
