Isolated Bone Marrow Involvement of Lepromatous Leprosy in an HIV-infected Patient with No Apparent Skin Lesions: A Case Report
https://doi.org/10.56026/imu.19.1.67
- Author:
Joshua Shadrach Daniel
1
;
Kwee Choy Koh
2
,
3
;
Thin Thin Win
4
Author Information
1. Medical Graduate, IMU University, Seremban, Negeri Sembilan, Malaysia
2. Deputy Dean, Clinical Science, Development &
3. Community Engagement, Infectious Diseases Consultant, IMU University, Seremban, Negeri Sembilan, Malaysia
4. Department of Pathology and Pharmacology, School of Medicine, IMU University, Bukit Jalil, Kuala Lumpur, Malaysia
- Publication Type:Journal Article
- Keywords:
Leprosy;
HIV;
Bone marrow involvement
- MeSH:
Leprosy;
HIV
- From:International e-Journal of Science, Medicine and Education
2025;19(1):67-70
- CountryMalaysia
- Language:English
-
Abstract:
Leprosy caused by Mycobacterium leprae, primarily manifests with cutaneous and neurological symptoms. Bone marrow (BM) involvement without skin lesions is exceedingly rare, particularly in immunocompromised patients. Here is a case of a 40-year-old HIV-infected man with a nadir CD4 count of 29 cells/mm³ who presented with recurrent anaemia, massive hepatosplenomegaly, and no apparent skin lesions. BM analysis revealed epithelioid granulomas with foamy histiocytes containing acid-fast bacilli, confirmed by Wade-Fite staining. This case highlights the rare presentation of lepromatous leprosy, emphasising the diagnostic challenges posed by the absence of typical cutaneous features.
- Full text:20250815104739862668.-Joshua-Isolated-Bone-Marrow-3.pdf
