Salivary amylase and adiponectin as potential non-invasive markers of glycaemic control in Malaysian type 2 diabetes mellitus participants
https://doi.org/10.56026/imu.14.1.8
- Author:
Helen Thong
1
;
Sangeetha Shyam
2
;
Ammu Radhakrishnan
1
,
3
;
Cheong Lieng Teng
4
Author Information
1. School of Medicine, International Medical University, Kuala Lumpur, MALAYSIA
2. Division of Nutrition and Dietetics, School of Health Sciences, International Medical University, Kuala Lumpur, MALAYSIA
3. Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Sunway, MALAYSIA
4. Department of Family Medicine, International Medical University, Clinical Campus, Seremban, Negeri Sembilan, MALAYSIA
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus (T2DM);
salivary adiponectin;
salivary amylase;
haemoglobin A1c (HbA1c)
- MeSH:
Diabetes Mellitus, Type 2;
Glycated Hemoglobin
- From:International e-Journal of Science, Medicine and Education
2020;14(1):8-21
- CountryMalaysia
- Language:English
-
Abstract:
Introduction:Serum amylase and adiponectin levels have shown promise as markers of cardio-metabolic diseases. However, the levels of these markers in saliva and their association with glycaemic management in diabetes mellitus (DM) are not well documented. Therefore, we investigated the correlation of salivary amylase and adiponectin concentrations with measures of glycaemic control in type 2 diabetes mellitus (T2DM) participants.
Methods:We conducted a cross-sectional study involving 80
T2DM participants of Indian and Malay ethnicity. Saliva
was collected, and salivary amylase and adiponectin
concentrations were analysed. Recent fasting blood
sugar and HbA1c of the participants was obtained form
their medical records. The correlations of salivary
amylase and adiponectin with fasting blood sugar and
HbA1c were calculated using Spearman’s correlation
Results:There was a weak positive correlation between salivary
adiponectin and HbA1c (rho = 0.221, p = 0.051). The
salivary adiponectin levels was significnalty lower among
participants with good glycaemic control (HbA1c ≤
7.0%) compared to those with poor glycaemic control
(HbA1c > 7.0%,) (1.13 (1.75) vs. 2.34 (3.54) ng/ml,
p = 0.039).
Conclusion:Salivary adiponectin weakly correlated with HbA1c,
while salivary amylase showed no correlation with
the glycaemic parameters studied. Therefore, salivary
adiponectin may warrant further investigation as a
potential non-invasive biomarker of T2DM.
- Full text:20250811144144313424.OriginalArticle-1.pdf
