EFFECT OF EXERCISE ON NON-HDL CHOLESTEROL LEVEL (NON-HDL-C) IN OLDER WOMEN: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
https://doi.org/10.22452/jummec.vol23no1.10
- Author:
Sai Wai Yan Myint Thu
1
;
Aung Phone Zaw
2
;
Pyae Phyo Kyaw
3
Author Information
1. Department of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
2. Department of Physiology, Defense Services Medical Academy, Yangon, Myanmar.
3. Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
- Publication Type:Journal Article
- Keywords:
Exercise;
Non-HDL-C;
Older Women;
Meta-analysis
- MeSH:
Exercise;
Meta-Analysis [Publication Type]
- From:Journal of University of Malaya Medical Centre
2020;23(1):49-59
- CountryMalaysia
- Language:English
-
Abstract:
Background:Many studies have shown that exercise can effectively reduce the non-high density lipoprotein cholesterol (non-HDL-C) level, one of the major risk factors for cardiovascular diseases, in different sex and age groups. However, there are very few studies conducted in older women, who are in a group having a higher mortality rate due to cardiovascular diseases. Moreover, there has been no recent meta-analysis focusing on the effect of exercise on non-HDL-C level in older women. The purpose of this study was to investigate the effect of exercise on non-HDL-C level in older women (≥50 years old) by means of systematic review and meta-analysis of previous randomised controlled trials.
Methods:Searches were conducted from 9 electronic databases by applying specific eligibility criteria of the review. Data regarding changes in non-HDL-C, high density lipoprotein cholesterol (HDL-C) and total cholesterol levels, were extracted as primary outcomes. Random-effect meta-analysis was used to calculate pooled effect sizes of primary and secondary outcomes.
Results:Ten studies that met the inclusion criteria were selected for meta-analysis. Random-effect meta-analysis showed statistically significant reduction in non-HDL-C level (= -9.69 mg/dL; 95%CI= -17.09 to -2.29 mg/dL; p<0.05) and increase in HDL-C level (= 3.0mg/dL; 95%CI= 0.61 to 5.4; p<0.05), but no significant change in total cholesterol level (= -5.99 mg/dL; 95%CI= -12.64 to 0.66; p>0.05) in the exercise group compared to the control group. Subgroup analysis of data from different continents showed significant subgroup differences in the non-HDL-C level after exercise (Q= 12.39; p<0.005; I2= 83.9%).
Conclusion:Exercise decreases non-HDL-C level and increases HDL-C level in older women and might be efficacious in preventing dyslipidemia and associated diseases in older women.
- Full text:202508111253355543151011.pdf
