Surveillance of measles, rubella and mumps antibody levels in healthy population in Pudong New Area of Shanghai from 2018 to 2022
10.13200/j.cnki.cjb.004537
- VernacularTitle:2018—2022年上海市浦东新区健康人群麻疹、风疹、流行性腮腺炎抗体水平监测
- Author:
YANG Dandan
- Publication Type:Journal Article
- Keywords:
Measles;
Rubella;
Mumps;
Healthy population;
Antibody level
- From:
Chinese Journal of Biologicals
2025;38(08):939-943+950
- CountryChina
- Language:Chinese
-
Abstract:
Objective To monitor the antibody levels against measles, mumps and rubella in healthy population in Pudong New Area of Shanghai from 2018 to 2022, so as to provide evidence for the improvement of immunization strategy.Methods A total of 1 305 healthy people from 16 communities in Pudong New Area, Shanghai were randomly sampled and divided into12 age groups(0 ～ < 8 months old to ≥ 50 years old). The levels of IgG antibodies against measles, rubella and mumps in venous blood serum were detected by ELISAResults One sample was discarded because no results were detected. In 1 304serum samples, the positive rates of measles, rubella and mumps IgG antibodies were 63. 65%, 48. 39% and 58. 21%, and the geometric mean concentrations(GMCs) of the antibodies were 229. 74 mIU/mL, 11. 63 IU/mL and 76. 43 U/mL, respectively.The positive rates of measles, rubella and mumps IgG antibodies(χ~2= 0. 01-4. 874, each P > 0. 05) and GMCs(t = 0. 020-2. 583,P > 0. 05) in the serum of healthy people of different genders and household registrations showed no statistically significant difference, while the positive rates of IgG antibodies(χ~2= 16. 865-667. 297, each P < 0. 01) and GMCs(t = 5. 862-117. 019,each P < 0. 001) in the serum of healthy people with different age, year and vaccination history exhibited statistically significant differences.Conclusion The antibody levels of measles, rubella and mumps among healthy population in Pudong New Area of Shanghai are related to the year, age and immunization history, and there is still a certain risk of infection. It is suggested to strengthen the monitoring of immune status of healthy population and vaccination of women at childbearing age related to measles, mumps and rubella, which will help reduce the risk of measles, rubella and mumps in healthy population under vaccination age.
