Long-Term Outcome of Amyotrophic Lateral Sclerosis in Korean Subjects.
10.5535/arm.2017.41.6.1055
- Author:
Mi Ri SUH
1
;
Won Ah CHOI
;
Young Chul CHOI
;
Jang Woo LEE
;
Jung Hwa HONG
;
Jihyun PARK
;
Seong Woong KANG
Author Information
1. Department of Medicine, The Graduate School, Yonsei University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Amyotrophic lateral sclerosis;
Survival;
Prognosis
- MeSH:
Age of Onset;
Amyotrophic Lateral Sclerosis*;
Diagnosis;
Humans;
Male;
Multivariate Analysis;
Noninvasive Ventilation;
Prognosis;
Proportional Hazards Models;
Survival Rate;
Tracheostomy
- From:Annals of Rehabilitation Medicine
2017;41(6):1055-1064
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To report the latest long-term outcome of amyotrophic lateral sclerosis (ALS) and to analyze the predictors of prognosis. METHODS: Subjects who were diagnosed with ALS between January 2005 and December 2009 at a single institute were followed up until death or up to December 2014. Data regarding age, sex, date of onset, date of diagnosis, presence of bulbar symptoms on onset, date of initiation of non-invasive ventilation (NIV), and the date of tracheostomy were collected. Survival was assessed using Kaplan-Meier curves and multivariate analyses of the risk of death were performed using the Cox proportional hazards model. RESULTS: Among 212 suspicious subjects, definite ALS was diagnosed in 182 subjects. The survival rate at 3 and 5 years from onset was 61.5% and 40.1%, respectively, and the survival rate at 3 and 5 years post-diagnosis was 49.5% and 24.2%, respectively. Further, 134 patients (134/182, 73.6%) were initiated on NIV, and among them, 90 patients (90/182, 49.5%) underwent tracheostomy. Male gender and onset age of ≥65 years were independent predictors of adverse survival. CONCLUSION: The analysis of long term survival in ALS showed excellent outcomes considering the overall poor prognosis of this disease.
