Research progress on nano-antimicrobial materials in root canal therapy
10.12016/j.issn.2096-1456.202550077
- Author:
WANG Yiyi
1
;
QIN Lu
1
;
JIA Yanmin
1
;
DU Xushuo
1
;
LIU Fei
2
;
WANG Suping
2
Author Information
1. School of Stomatology, Zhengzhou University
2. Department of Stomatology, The First Affiliated Hospital of Zhengzhou University
- Publication Type:Review
- Keywords:
endodontic disease;
periapical disease;
root canal therapy;
metal nanoparticles;
antimicrobial nanoparticles;
silver nanoparticles;
zinc oxide nanoparticles;
chitosan nanoparticles;
calcium hydroxide nanoparticles;
quaternary ammonium polyethyleneimine nanoparticles;
nano-delivery systems;
mesoporous calcium silicate nanoparticles;
mesoporous silica nanoparticles
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2025;33(8):699-708
- CountryChina
- Language:Chinese
-
Abstract:
The efficacy of root canal therapy, as a core intervention for endodontic and periapical diseases, is highly dependent on the effectiveness of antimicrobial drugs. Although traditional drugs such as calcium hydroxide, chlorhexidine, and antibiotic pastes commonly used in the clinic play a role in preventing and controlling infections, they have obvious limitations. These drugs influence the mechanical properties of dentin, insufficiently solubilize necrotic tissues, and are susceptible to bacterial resistance, which makes achieving the desired effectiveness and safety difficult. Traditional macromolecular root canal drugs also face the challenge of the complexity of the root canal system. With the rapid development of material science in recent years, new antimicrobial agents have emerged. Metallic nanomaterials such as silver nanoparticles and zinc oxide nanoparticles are widely used in the medical field due to their unique physicochemical properties and superior antimicrobial properties. Chitosan nanoparticles have superior biosafety, calcium hydroxide nanoparticles compensate for the limitations of traditional calcium hydroxide formulations, and quaternary ammonium polyethyleneimine nanoparticles can confer antimicrobial properties to existing oral materials. Novel antimicrobial nanoparticles using nano-delivery systems, such as mesoporous calcium silicate and mesoporous silica, carry antimicrobial molecules with significant advantages in terms of anti-biofilm, biosafety, and promotion of tissue repair. Further, these agents reduce drug resistance, which improves prospects for application compared to traditional root canal disinfection drugs. The breakthrough of nanotechnology provides a novel direction for the innovation of root canal treatment drugs. Therefore, this paper reviews the research progress of nano-antimicrobial materials in root canal therapy.
- Full text:202508061518293457纳米抗菌材料在根管治疗中的研究进展.pdf
