The role and mechanisms of gingival epithelial cells in maintaining periodontal homeostasis
10.12016/j.issn.2096-1456.202550044
- Author:
WANG Xiao
1
,
2
,
3
,
4
;
WU Yajie
1
,
2
,
3
,
4
;
SU Zhifei
1
,
2
,
3
,
5
;
LI Jiyao
1
,
2
,
3
,
4
Author Information
1. State Key Laboratory of Oral Diseases &
2. National Center for Stomatology &
3. National Clinical Research Center for Oral Diseases &
4. Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University
5. Department of Oral Comfort Care Center, West China Hospital of Stomatology, Sichuan University
- Publication Type:Review
- Keywords:
gingival epithelial cells;
periodontal homeostasis;
epithelium barrier;
epithelial-mesenchymal transition;
apoptosis;
immune responses;
oral microorganisms;
immune cell
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2025;33(8):672-679
- CountryChina
- Language:Chinese
-
Abstract:
Periodontal homeostasis is regulated by the complex interplay between the gingival epithelial barrier, the extracellular matrix of soft tissues, the bone coupling system, and immune responses within the periodontal region. Gingival epithelial cells are primarily composed of keratinocytes and a small proportion of non-keratinocytes, and they are integral to the formation of the gingival epithelial barrier. This epithelial barrier plays a fundamental role in defending against pathogens, exogenous substances, and mechanical stress. This study aims to explore the intrinsic connections between gingival epithelial cells and periodontal homeostasis. Research has shown that gingival epithelial cells participate in maintaining periodontal homeostasis through multiple pathways: ① gingival epithelial cells respond to the inflammatory environment by undergoing proliferation, migration, epithelial-mesenchymal transition, and forming apoptosis-mediated neutrophil extracellular traps; ② when gingival inflammation damages the epithelial barrier, lipopolysaccharides cannot be easily removed, and gingival epithelial cells play a defensive role by activating innate immune responses; ③ the interactions of gingival epithelial cells with oral microbiota and immune cells are essential for maintaining periodontal homeostasis. Thus, gingival epithelial cells are closely associated with periodontal homeostasis. However, the crucial role and mechanisms of gingival epithelial cells in the maintenance of periodontal homeostasis are not clear, which provides novel insights for the research of periodontal homeostatic medicine.
- Full text:2025080614455664497牙龈上皮细胞在牙周稳态维持中的作用及机制.pdf
