Risk factors of cardiovascular events by low density lipoprotein cholesterol
10.3969/j.issn.1006-2483.2025.04.024
- VernacularTitle:低密度脂蛋白胆固醇对心血管事件的危险因素
- Author:
Caixia WANG
1
;
Zhiyou ZENG
1
;
Zhaoming PENG
1
Author Information
1. Department of Family Medicine , Fourteen Sixth Hospital of Nuclear Industry , Chengdu , Sichuan 610051 , China
- Publication Type:Journal Article
- Keywords:
Low density lipoprotein cholesterol;
Stable angina pectoris;
Acute myocardial infarction
- From:
Journal of Public Health and Preventive Medicine
2025;36(4):106-109
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate and analyze the risk factors of cardiovascular events by low density lipoprotein cholesterol (LDL-C). Methods A total of 430 patients with stable angina pectoris (SAP) in the hospital were included from June 2021 to June 2024 for retrospective analysis. According to whether acute myocardial infarction (AMI) occurred, the enrolled patients were divided into stable group (n=257) and deteriorating group (n=173). The general data were compared between groups, and the risk factors affecting AMI in SAP patients were analyzed. The predictive value of the above risk factors on predicting AMI in SAP patients was analyzed. Results Compared with the stable group, the levels of LDL-C, TG, LP-a and Hcy in the deteriorating group were higher (t=4.033, P<0.001; t=4.104, P<0.001; t=6.342, P<0.001; t=4.883, P<0.001) while the HDL-C level was lower (t=5.129, P<0.001). Multivariate logistic regression analysis suggested that the elevated levels of LDL-C, TG, LP-a and Hcy were the risk factors of AMI in SAP patients (P<0.05), and the elevated level of HDL-C was a protective factor (P<0.05). In the ROC curve, the area under the curve (AUC), sensitivity and specificity of combination of LDL-C, HDL-C, TG, LP-a and Hcy in predicting AMI in SAP patients were 0.777, 63.01% and 81.71%. Conclusion LDL-C is a risk factor of AMI in SAP patients. Combination of HDL-C, TG, LP-a and Hcy has certain value on predicting AMI in SAP patients.
