Correlation between serum cystatin C and bone turnover markers in elderly patients with type 2 diabetes mellitus and osteoporosis
10.3969/j.issn.1006-2483.2025.04.020
- VernacularTitle:2型糖尿病合并骨质疏松老年患者血清胱抑素C与骨转换标志物的相关性
- Author:
Mengqian WANG
1
,
2
,
3
;
Shaohong ZHANG
1
,
2
,
3
;
Mengyue SUN
1
,
2
,
3
;
Min CHEN
1
,
2
,
3
;
Weimin WANG
1
,
2
,
3
Author Information
1. Department of Geriatrics , Huai'
2. an First People's Hospital , Huai'
3. an , Jiangsu 223300 , China
- Publication Type:Journal Article
- Keywords:
Senile type 2 diabetes mellitus;
Osteoporosis;
Cystatin C;
Bone turnover marker;
Correlation
- From:
Journal of Public Health and Preventive Medicine
2025;36(4):89-92
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between serum cystatin C (Cys-C) and bone turnover markers in elderly patients with type 2 diabetes mellitus (T2DM) and osteoporosis. Methods A retrospective analysis was conducted on the data of 320 elderly patients with T2DM admitted to Huai'an First People's Hospital from August 2021 to June 2024. Patients were divided into the osteoporosis group and the non-osteoporosis group according to whether they had osteoporosis. General information, bone turnover markers, and serum Cys-C levels were collected from all patients. The data were compared between the two groups to analyze the influencing factors of osteoporosis in elderly patients with T2DM and the correlation between serum Cys-C and bone turnover markers. Results The levels of total cholesterol and LDL-C in the osteoporosis group were higher than those in the non-osteoporosis group, and the bone mineral density was lower than that in the non-osteoporosis group (P<0.05). The levels of TPINP, β-CTX, and Cys-C in the osteoporosis group were higher than those in the non-osteoporosis group, and 25-OH-D3 level was lower than that in the non-osteoporosis group (P<0.05). Serum Cys-C was positively correlated with TPINP and β-CTX, and negatively correlated with 25-OH-D3 (P<0.05). Multivariate logistic regression analysis found that total cholesterol, LDL-C, TPINP, β-CTX, 25-OH-D3, and Cys-C were factors influencing osteoporosis in elderly patients with T2DM (P<0.05). Conclusion Serum Cys-C levels in elderly patients with T2DM and osteoporosis are elevated. There is a significant correlation between Cys-C level and bone turnover markers.
