Risk factors for liver cancer in 504 patients with hepatitis B virus associated cirrhosis logistic regression analysis
10.3969/j.issn.1006-2483.2025.04.019
- VernacularTitle:504例乙型肝炎病毒相关肝硬化患者发生肝癌危险因素logistic回归分析
- Author:
Gang LI
1
;
Hongliang SHANG
1
;
Yuanyuan LIU
1
;
Rui JIN
2
;
Cheng WANG
1
;
Yajuan XIE
3
Author Information
1. First Ward , Department of Gastroenterology , Hanzhong City Center Hospital ,Hanzhong , Shaanxi 723000 , China
2. Second Ward , Department of Gastroenterology , Hanzhong City Center Hospital ,Hanzhong , Shaanxi 723000 , China
3. Electrocardiography Room , Hanzhong City Center Hospital ,Hanzhong , Shaanxi 723000 , China
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus-related cirrhosis;
Liver cancer;
Risk factors
- From:
Journal of Public Health and Preventive Medicine
2025;36(4):85-88
- CountryChina
- Language:Chinese
-
Abstract:
Objective Logistic regression model was used to analyze the risk factors of liver cancer in patients with hepatitis B virus-related cirrhosis. Methods A retrospective analysis was performed on 504 patients with hepatitis B cirrhosis who were treated in a hospital from April 2021 to April 2024. The occurrence of liver cancer was counted. The risk factors of liver cancer in patients with HBV-related cirrhosis were analyzed by logistic regression analysis. Results Among the 504 patients with hepatitis B cirrhosis, 101 patients developed liver cancer and 403 patients did not develop liver cancer, which were included in the liver cancer group (n=101) and the non-liver cancer group (n=403).. Among hepatitis B cirrhosis, the incidence rate of liver cancer was 20.04%. Compared with the non-liver cancer group, the proportion of patients with long-term drinking history, family history of liver cancer, history of diabetes mellitus, antiviral therapy, and HBV-DNA load>104 were higher in the liver cancer group (P<0.05). logistic regression analysis found that long-term drinking history (OR=3.077, 95%CI: 1.130-8.378, P=0.028), history of diabetes mellitus (OR=3.747, 95%CI: 1.765-7.954, P=0.001), no antiviral therapy (OR=3.466, 95%CI: 1.337-8.985, P=0.011) and HBV-DNA load>104 (OR=3.149, 95%CI: 1.353-7.328, P=0.008) could independently affect the occurrence of liver cancer in patients with hepatitis B cirrhosis. Conclusion According to logistic regression analysis, long-term drinking history, history of diabetes mellitus, no antiviral therapy, and HBV-DNA load>104 are risk factors for liver cancer in patients with HBV-related cirrhosis.
