Incidence rate and independent risk factors of synchronous multiple lesions in early gastric cancer
10.3969/j.issn.1006-2483.2025.04.018
- VernacularTitle:早期胃癌中同时性多发病灶的发生率及其独立危险因素
- Author:
Yanqing ZHOU
1
;
Yue YANG
1
;
Yu XIAO
1
;
Hongyong LI
1
;
Zhen NI
1
Author Information
1. Department of Infection , General Hospital of Western Theater Command , Chengdu , Sichuan 610083, China
- Publication Type:Journal Article
- Keywords:
Synchronous multiple early gastric cancer;
Incidence rate;
Chronic atrophic gastritis;
Moderate-to-severe intestinal metaplasia
- From:
Journal of Public Health and Preventive Medicine
2025;36(4):81-84
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the incidence rate and independent risk factors of synchronous multiple early gastric cancer (SMEGC) in patients with early gastric cancer, and to provide evidence for early screening and intervention of high-risk population. Methods A retrospective analysis was performed on 308 patients with early gastric cancer who received treatment in the hospital from March 2019 to March 2024. The incidence rate of SMEGC was counted, and the risk factors were analyzed by univariate and multivariate Logistic regression analyses. Results Among the 308 patients with early gastric cancer in this study, 23 cases were SMEGC and 285 were single early gastric cancer, which were included in the SMEGC group and the single group respectively. The incidence rate of SMEGC was 7.47% (23/308). Compared with the single group, the proportions of male, smoking history, tumor diameter≤2 mm, chronic atrophic gastritis and intestinal metaplasia degree were higher in the SMEGC group (2=4.331、8.608、4.618、6.490、4.897，P=0.037、0.003、0.032、0.001、0.027). Logistic regression analysis suggested that chronic atrophic gastritis (OR=3.133, 95%CI: 1.240-7.918) and moderate-to-severe intestinal metaplasia (OR=3.171, 95%CI: 1.252-8.029) were independent risk factors for SMEGC (P<0.05). Conclusion Some patients with early gastric cancer are SMEGC. Chronic atrophic gastritis and moderate-to-severe intestinal metaplasia are independent risk factors affecting the occurrence of SMEGC. It is recommended to regularly screen high-risk patients and optimize management strategies to reduce the risk of SMEGC.
