Correlation of levels of serum Visfatin, CXCL12 and Sirt1 with carotid atherosclerosis in patients with T2DM
10.3969/j.issn.1006-2483.2025.04.013
- VernacularTitle:2型糖尿病患者血清Visfatin，CXCL12，Sirt1水平与颈动脉粥样硬化的相关性分析
- Author:
Ali YANG
1
,
2
;
Shujuan DENG
3
,
4
Author Information
1. Department of Endocrinology, The First People'
2. s Hospital of Xianyang , Xianyang , Shaanxi 712000 , China
3. Department of General Medicine, The First People'
4. s Hospital of Xianyang , Xianyang , Shaanxi 712000 , China
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Carotid atherosclerosis;
Visfatin;
CXC chemokine 12;
Silent information regulator
- From:
Journal of Public Health and Preventive Medicine
2025;36(4):60-63
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum Visfatin, CXC chemokine 12 (CXCL12) and silent information regulator 1 (Sirt1) levels and carotid atherosclerosis (CAS) in patients with type 2 diabetes mellitus (type 2 diabetes mellitus ,T2DM). Methods Four hundred and ninety-five patients with T2DM in the hospital from July 2021 to June 2023 were selected as the observation group, and 50 healthy volunteers were included in the control group. The levels of serum Visfatin, CXCL12 and Sirt1 were detected, and the above levels were compared between groups. The patients in the observation group were divided into simple T2DM group and T2DM with CAS group by means of the results of carotid ultrasound examination, and the clinical data were compared. Multivariate Logistic regression analysis was performed to analyze the factors affecting the occurrence of CAS in T2DM patients. Spearman correlation analysis of serum Visfatin, CXCL12 and Sirt1 levels and severity of CAS was analyzed by Spearman correlation analysis. Results Compared with the control group, the levels of serum Visfatin and CXCL12 in the observation group were higher (t=14.524, t=11.536, all P<0.05) while the level of Sirt1 was lower (t=21.912, P<0.05). There were statistical differences in age, body mass index (BMI), FBG, HbAlc, FINS, TG, LDL-C, Visfatin, CXCL12 and Sirt1 between T2DM with CAS group and simple T2DM group (P<0.05). Multivariate analysis suggested that age (OR=2.155), FBG (OR=2.563), HbAlc (OR=2.472), FINS (OR=0.438), TG (OR=2.492), LDL-C (OR=2.445), Visfatin (OR=2.404), CXCL12 (OR=2.214) and Sirt1 (OR=0.398) were the influencing factors of CAS in patients with T2DM (P<0.05). The levels of serum Visfatin and CXCL12 were positively correlated with the severity of CAS (r=0.574, r=0.530, P<0.05), and the level of Sirt1 was negatively correlated with the severity of CAS (r=-0.621, P<0.05). Conclusion Serum Visfatin, CXCL12 and Sirt1 in T2DM patients are related to the occurrence and severity of CAS. Visfatin, CXCL12 and Sirt1 may be involved in the occurrence and development of CAS in T2DM patients.
