Progress of researches on mechanisms underlying immune escape of Plasmodium
10.16250/j.32.1915.2024214
- VernacularTitle:疟原虫免疫逃逸机制研究进展
- Author:
Yuhuang WU
1
,
2
;
Jing HE
1
,
2
;
Xinghang CAO
3
;
Juntong LI
1
;
Shuchu SHEN
1
;
Youqin DU
1
;
Chao TAN
4
Author Information
1. Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Yichang Key Laboratory of Infection and Inflammation, College of Basic Medical Sciences, China Three Gorges University, Yichang, Hubei 443002, China
2. Co-first authors
3. College of Science and Technology, China Three Gorges University, Hubei Province, China
4. The First College of Clinical Medical Sciences, China Three Gorges University, Yichang, Hubei 443001, China
- Publication Type:Journal Article
- Keywords:
Plasmodium;
Immune escape;
Antigen;
Epigenetic modification
- From:
Chinese Journal of Schistosomiasis Control
2025;37(3):325-331
- CountryChina
- Language:Chinese
-
Abstract:
Malaria, a parasitic disease caused by infection with the species of Plasmodium and transmitted by Anopheles mosquito bites, is one of the major public health challenges that seriously threaten human health. Malaria parasites present diverse immune escape strategies to escape from the recognition and clearance of the host immune system, which poses a great challenge to the malaria control programme. This review presents the advances in the mechanisms underlying the immune escape of Plasmodium, including antigenic variation, epigenetic regulation, antagonism against IgM antibody, activation of the cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) synthase-stimulator of interferon genes (cGAS-STING) signaling, suppression of splenic immune functions, and molecular camouflage, so as to provide insights into development of malaria vaccines and antimalarial agents and formulation of the malaria control strategy.
