Application and prospect of artificial intelligence and population pharmacokinetics in personalized medication after organ transplantation
- VernacularTitle:人工智能与群体药动学模型在器官移植术后个体化用药中的应用与展望
- Author:
Shuai HE
1
;
Huiying ZONG
1
;
An’an LI
1
;
Penglin ZHOU
1
;
Rui GAO
1
;
Xichao WU
1
;
Yanjiao ZHU
1
;
Yan LI
1
Author Information
1. Shandong Qianfoshan Hospital
- Publication Type:Journal Article
- Keywords:
artificial intelligence;
population pharmacokinetics;
organ transplantation;
individualized medication
- From:
China Pharmacy
2025;36(14):1813-1818
- CountryChina
- Language:Chinese
-
Abstract:
Artificial intelligence （AI） and population pharmacokinetics （PPK） technologies have demonstrated significant potential in the personalized medication of immunosuppressants after organ transplantation, enabling precise prediction of drug dosages. This article provides a comprehensive review of the application status of AI and PPK in the individualized administration of immunosuppressants after organ transplantation， focuses on monitoring blood drug concentration， predicting efficacy/adverse reactions， and establishing individualized dosing models for organ transplant recipients after immunosuppressant administration， and analyzes and compares the application characteristics of different methods in different organ transplant patients as well as the integration and future development of AI and PPK technologies. AI and PPK technologies can not only significantly reduce the dependence on human resources， but also greatly improve the level of individualized treatment of immunosuppressants after organ transplantation， and reduce the discomfort and burden caused by frequent blood concentration monitoring to patients.
