Research progress on the prevention and treatment of myocardial infarction by traditional Chinese medicine through regulating NF-κB signaling pathway
- VernacularTitle:中药调控NF-κB信号通路防治心肌梗死的研究进展
- Author:
Lirong ZHENG
1
,
2
;
Peili YANG
1
,
2
;
Guiwei LI
3
;
Junchi GUO
1
,
2
;
Yingqiang ZHAO
1
Author Information
1. Dept. of Cardiology，the Second Affiliated Hospital of Tianjin University of TCM，Tianjin 300250，China
2. Graduate School，Tianjin University of Traditional Chinese Medicine，Tianjin 301617，China
3. Dept. of Emergency，the First Affiliated Hospital of Tianjin University of TCM，Tianjin 300110，China
- Publication Type:Journal Article
- Keywords:
myocardial infarction;
NF-κB;
traditional Chinese medicine;
active ingredients;
compound formula
- From:
China Pharmacy
2025;36(14):1807-1812
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial infarction （MI） refers to an acute clinical syndrome of myocardial necrosis due to persistent ischemia and hypoxia， resulting from the sharp reduction or interruption of coronary blood flow. Nuclear factor κB （NF-κB） is the key factor in inducing inflammatory response， and it is involved in the production of pro-inflammatory factors and myocardial cell apoptosis. This article systematically describes the molecular regulation mechanism of the NF-κB signaling pathway in MI， and reviews the related research on the prevention and treatment of MI through the regulation of this signaling pathway by active ingredients and compound formulas from traditional Chinese medicine （TCM）. It has been found that active ingredients from TCM， such as ginsenoside Rg3， baicalein， curcumin， tanshinone ⅡA， gambogic acid， as well as compound formulas， including Qili qiangxin capsules， Yiqi huoxue decoction， Lingbao huxin dan， Danhong injection， Baoyuan decoction combined with Taohong siwu decoction， can improve myocardial fibrosis， alleviate inflammatory responses， and inhibit cardiomyocyte apoptosis by suppressing the NF-κB signaling pathway. Thereby， they achieve the goal of preventing and treating MI.
