Prospective Study on Tooth Loss and Risk of Esophageal Cancer Among Residents of A Natural Village in Wenfeng District, Anyang City, Henan Province

Jingjing WANG; Ruihua XU; Yanfang ZHANG; Xueke ZHAO; Qiang ZHANG; Xin SONG; Mengxia WEI; Junfang GUO; Xuena HAN; Yaru FU; Bei LI; Junqing LIU; Lingling LEI; Min LIU; Qide BAO; Lidong WANG

Return

Prospective Study on Tooth Loss and Risk of Esophageal Cancer Among Residents of A Natural Village in Wenfeng District, Anyang City, Henan Province

VernacularTitle:河南省安阳市文峰区某自然村居民牙齿脱落与食管癌风险前瞻性研究
Author: Jingjing WANG ¹ ; Ruihua XU ² ; Yanfang ZHANG ¹ ; Xueke ZHAO ² ; Qiang ZHANG ¹ ; Xin SONG ² ; Mengxia WEI ² ; Junfang GUO ¹ ; Xuena HAN ² ; Yaru FU ¹ ; Bei LI ² ; Junqing LIU ¹ ; Lingling LEI ² ; Min LIU ¹ ; Qide BAO ¹ ; Lidong WANG ²
Author Information

1. Anyang District Hospital, Anyang 455000, China.
2. State Key Laboratory of Esophageal Cancer Prevention and Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Publication Type:SPECIALFEATURE
Keywords: Risk factor; Tooth loss; Esophageal cancer; Cohort study
From: Cancer Research on Prevention and Treatment 2025;52(7):548-553
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between tooth loss and the occurrence of esophageal cancer in a natural village in Wenfeng District, Anyang City, Henan Province. Methods A prospective cohort study was conducted to observe the occurrence of tooth loss and esophageal cancer among the asymptomatic residents of the natural village for 16 years from January 2008 to July 2024. Data were analyzed by chi-square test, binary logistic regression, and restricted cubic spline. Results Among the total population of 711 cases, 136 cases were lost to follow-up and 575 cases were included in the final statistics, including 45 cases with esophageal cancer. Significant statistical difference was found between esophageal cancer patients with and without tooth loss (P<0.05). Logistic regression analysis showed that tooth loss was associated with the occurrence of esophageal cancer (OR=3.977, 95%CI: 1.543-10.255). After the adjustment for confounders, tooth loss remained significantly associated with the occurrence of esophageal cancer (OR=3.038, 95%CI: 1.035-8.914). A nonlinear dose-response relationship was observed between the number of teeth lost and the incidence of esophageal cancer. When the number of teeth lost was less than 12, the risk of esophageal cancer increased with the number of teeth lost. When more than 12 teeth were lost, the risk of esophageal cancer decreased as the number of teeth lost increased. Conclusion Tooth loss is a risk factor for the occurrence of esophageal cancer in this natural village. When the number of teeth lost is less than 12, the risk of esophageal cancer increases with the number of teeth lost.