Efficacy of implantable neuromuscular electrical stimulation system on stress urinary incontinence model in female rats
10.3969/j.issn.1009-8291.2025.05.012
- VernacularTitle:植入式神经肌肉电刺激系统对雌性大鼠压力性尿失禁模型的疗效观察
- Author:
Bohong LONG
1
,
2
;
Chen LI
3
;
Han DENG
3
;
Haoyu SUN
3
;
Limin LIAO
3
;
Xing LI
1
,
2
Author Information
1. Department of Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325035
2. Department of Urology, Rehabilitation School of Capital Medical University, China Rehabilitation Research Center, Beijing 100068, China
3. Department of Urology, Rehabilitation School of Capital Medical University, China Rehabilitation Research Center, Beijing 100068, China
- Publication Type:Journal Article
- Keywords:
stress urinary incontinence;
pelvic floor muscle training;
implantable neuromuscular stimulation;
leak point pressure;
female rats
- From:
Journal of Modern Urology
2025;30(5):438-441
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the efficacy of implantable neuromuscular electrical stimulation system on stress urinary incontinence (SUI) model in female rats. Methods: A total of 21 female infertile SD rats were randomly divided into the control，sham stimulation，and stimulation groups，with 7 rats in each group.All rats received vaginal dilation (VD) to simulate postpartum SUI.One week after VD，the control group was given normal feeding，stimulators were implanted in the pelvic floor muscles of the sham stimulation and stimulation groups.The sham stimulation group received normal feeding for 2 weeks，and the stimulation group received pelvic floor electrical stimulation (PFES) for 2 consecutive weeks.The leak point pressure (LPP) of each rat was measured with cystometry before VD (baseline value)，1 week after VD，and 2 weeks after PFES. Results: In the control group and sham stimulation group，LPP increased after 2 weeks of treatment compared with that after 1 week of VD，but it still did not return to the baseline level (P<0.001).In the stimulation group，after 2 consecutive weeks of PFES，LPP increased significantly compared with that 1 week after VD，and returned to the baseline value (P>0.05).There was no significant difference in the LPP baseline values and levels after 1 week of VD among the 3 groups (P>0.05).The LPP in the stimulation group after 2 weeks of PFES was significantly higher than that in the sham stimulation group and stimulation group (P<0.001). Conclusion: The implantable neuromuscular electrical stimulation system is effective in short-term intervention of SUI in female rats，the further studies are needed to confirm the long-term efficacy and safety of the system，the optimal stimulation sites，optimal stimulation parameters，and potential mechanisms of action.
