Literature analysis of the differences in the occurrence of urinary epithelial carcinoma after kidney transplantation between northern and southern China

Pengjie WU; Runhua TANG; Dong WEI; Yaqun ZHANG; Hong MA; Bin JIN; Xin CHEN; Jianlong WANG; Ming LIU; Yaoguang ZHANG; Ben WAN; Jianye WANG

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Literature analysis of the differences in the occurrence of urinary epithelial carcinoma after kidney transplantation between northern and southern China

VernacularTitle:肾移植术后患者发生尿路上皮癌中国南北方差异的文献分析
Author: Pengjie WU ¹ ; Runhua TANG ^{1
,

2} ; Dong WEI ¹ ; Yaqun ZHANG ¹ ; Hong MA ¹ ; Bin JIN ¹ ; Xin CHEN ¹ ; Jianlong WANG ^{1
,

2} ; Ming LIU ^{1
,

2} ; Yaoguang ZHANG ^{1
,

2} ; Ben WAN ¹ ; Jianye WANG ^{1
,

2}
Author Information

1. Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730
2. Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Publication Type:Journal Article
Keywords: kidney transplantation; urothelial carcinoma; non-urothelial carcinoma; tumor of the transplanted kidney; northern and southern China
From: Journal of Modern Urology 2025;30(5):432-437
CountryChina
Language:Chinese
Abstract: Objective: To investigate the regional differences in the incidence of urothelial carcinoma among kidney transplant recipients between northern and southern China，so as to provide reference for early diagnosis of this disease. Methods: A comprehensive search was conducted across multiple databases，including CNKI，Wanfang，CBM，and PubMed，using the keywords “kidney transplantation” and “tumor” to collect clinical data from qualified kidney transplant centers.The latest and most complete literature data published by 17 transplant centers in northern China and 14 in southern China were included.Statistical analyses were performed to compare the incidence of post-transplant urothelial carcinoma and non-urothelial malignancies. Results: A total of 37 475 kidney transplant recipients were included，among whom 837 (2.23%) developed post-transplant malignancies，including urothelial carcinoma (366/837，43.73%)，non-urothelial carcinoma (444/837，53.05%)，and malignancies with unspecified pathology (27/837，3.23%).The incidence of malignancies was significantly higher in northern China than in southern China [(2.82±1.39)% vs. (1.67±0.83)%，P=0.011]，with a particularly pronounced difference in the incidence of urothelial carcinoma [(1.68±1.12)% vs. (0.32±0.32)%，P<0.001].No significant difference was observed in the incidence of non-urothelial carcinoma between the two regions [(1.11±0.56)% vs. (1.35±0.65)%，P=0.279].Additionally，female transplant recipients exhibited a higher incidence of malignancies than males in both regions (southern China：2.38% vs. 1.80%; northern China：8.93% vs. 2.52%). Conclusion: The incidence of urothelial carcinoma following kidney transplantation is significantly higher in northern China than in southern China，underscoring the importance of implementing regular tumor screening for kidney transplant recipients，particularly for female patients in northern China，to facilitate early diagnosis and timely intervention.