Relationship between metabolic score for insulin resistance and overactive bladder in the US population based on NHANES data from 2005 to 2018
10.3969/j.issn.1009-8291.2025.05.009
- VernacularTitle:基于2005-2018年NHANES数据分析胰岛素抵抗代谢评分指数与美国人膀胱过度活动症的关系
- Author:
Guoliang XU
1
;
Feiyang GAO
1
;
Xihao WANG
1
;
Jiangtao ZHU
1
;
Wei LIN
1
;
Pengyue LIU
1
;
Yongjun YAN
1
Author Information
1. Department of Urology, The First Affiliated Hospital of Henan University, Kaifeng 475000, China
- Publication Type:Journal Article
- Keywords:
metabolic score for insulin resistance index;
overactive bladder;
NHANES database;
insulin resistance;
metabolic syndrome
- From:
Journal of Modern Urology
2025;30(5):416-423
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To assess the association between the metabolic score for insulin resistance index (METS-IR) and overactive bladder (OAB) in the US population，so as to explore the potential of METS-IR as a predictive tool for OAB risk and to provide insights for early screening and intervention strategies. Methods: Based on the data from the National Health and Nutrition Examination Survey (NHANES) 2005-2018，a cross-sectional design was employed，and multivariate logistic regression models were used to analyze the association between METS-IR and OAB. METS-IR was analyzed both as a continuous variable and categorized into quartiles. To further validate the association between METS-IR and OAB across diverse populations，subgroup analyses were conducted in participants stratified by clinical characteristics. Smooth curve fitting was employed to test the linearity of the METS-IR-OAB relationship. Results: Elevated METS-IR was associated with an increased risk of OAB (P<0.001)，and this positive correlation remained stable when METS-IR was categorized into quartiles (P<0.001). Subgroup analyses revealed that the association between METS-IR and OAB was more pronounced in females，participants younger than 55 years，and non-diabetic individuals (P<0.05). Furthermore，smooth curve fitting confirmed a linear positive correlation between METS-IR and OAB，with this linear relationship observed in both diabetic and non-diabetic groups. Conclusion: This study，based on the NHANES 2005-2018 database，found a linear positive correlation between METS-IR and OAB.
