Mendelian randomization analysis of the relationship between gut microbiota and renal cell carcinoma
10.3969/j.issn.1009-8291.2025.03.013
- VernacularTitle:肠道菌群与肾细胞癌关系的孟德尔随机化分析
- Author:
Lingyu GUO
1
;
Tie CHONG
1
Author Information
1. Department of Urology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China
- Publication Type:Journal Article
- Keywords:
renal cell carcinoma;
gut microbiota;
inverse variance weighted;
single nucleotide polymorphism;
Mendelian randomization
- From:
Journal of Modern Urology
2025;30(3):248-254
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the correlation between gut microbiota and renal cell carcinoma (RCC) with Mendelian randomization analysis. Methods: Data involved with genome-wide association of the gut microbiome were retrieved from MiBioGen Consortium as the exposure group data，and RCC data were obtained from the FinnGen GWAS database.Next，a rigorous Mendelian randomization analysis was conducted utilizing multiple methods，including inverse variance weighted (IVW)，MR-Egger，maximum likelihood，and weighted median.Additionally，sensitivity analysis was performed to address heterogeneity and horizontal pleiotropy concerns. Results: A total of 2564 single nucleotide polymorphisms (SNPs) from the complete gut microbiota were analyzed.IVW analysis showed that bacillus (OR=0.780，95% CI:0.614-0.991，P=0.042) and anaerobic bacillus (OR=0.723，95% CI:0.533-0.981，P=0.037) reduced the risk of RCC.Actinomycetes (OR=1.302，95% CI：1.015-1.672，P=0.038)，family Ⅺ (OR=1.197，95% CI: 1.023-1.400，P=0.024)，coprococcus 2 genera (OR=1.440，95% CI：1.046-1.982，P=0.026)，clostridium lactate (OR=1.732，95% CI:1.254-2.392，P=0.001) and Odoribacter (OR=1.685，95% CI:1.150-2.469，P=0.007) were associated with an increased risk of RCC.Sensitivity analysis did not identify any abnormal SNPs，indicating the robustness and reliability of our findings. Conclusion: There may be a cause-and-effect relationship between different types of gut microbiota and genetically predited renal cell carcinoma，and different microbiota may be respectively associated with an increase or decrease in RCC.
