Analysis of intraocular pressure changes and factors mediated by PI3K/AKT-MMP-2 pathway in myopia development
10.3980/j.issn.1672-5123.2025.8.15
- VernacularTitle:眼压变化及PI3K/AKT-MMP-2通路介导与近视进展的因素分析
- Author:
Haojing WANG
1
;
Pubo WANG
1
;
Yane GAO
1
Author Information
1. Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
myopia;
intraocular pressure;
axial length;
choroidal blood flow;
scleral matrix remodeling;
PI3K/AKT signaling pathway
- From:
International Eye Science
2025;25(8):1296-1301
- CountryChina
- Language:Chinese
-
Abstract:
Myopia prevalence is still rising worldwide, addressing the worldwide myopia “epidemic” is of utmost importance, since the World Health Organization estimates that half of the world's population will suffer from myopia by the middle of the century. In addition to causing vision loss, myopia is closely associated with irreversible blinding disorders such as glaucoma and retinopathy. The pathophysiology of myopia is strongly linked to the biomechanical effects of intraocular pressure(IOP)on the scleral structure. Scleral tissue undergoes considerable structural remodelling during myopia development, increasing its sensitivity to the mechanical stresses of IOP. Important mechanisms include increased collagen degradation brought on by matrix metalloproteinase(MMP-2)activity, extracellular matrix dynamics destabilization from an imbalance in the regulation of tissue inhibitor of metalloproteinase(TIMPs), aberrant choroidal blood supply brought on by activation of the hypoxia-inducible factor-1α(HIF-1α)pathway, and cascading regulation of the PI3K/AKT signaling pathway in scleral remodeling. This study provides a significant scientific foundation and fresh concepts for the future research into myopia prevention and control strategies by methodically examining the connection between changes in IOP and the development of myopia as well as its molecular underpinnings.
