Research progress and pharmaceutical considerations of representative adjuvants in approved vaccines
10.13200/j.cnki.cjb.004526
- VernacularTitle:已上市疫苗中代表性佐剂的研究现状及药学考虑
- Author:
JIN Su
- Publication Type:Journal Article
- Keywords:
Vaccine;
Adjuvant;
Immune response
- From:
Chinese Journal of Biologicals
2025;38(07):890-896
- CountryChina
- Language:Chinese
-
Abstract:
With the ability to enhance the vaccine potency and efficacy significantly, adjuvants are the key focus in the field of vaccine research and development. However, during the research and development process, studies on adjuvant screening,characterization, formulation, quality, and other aspects are often overlooked. This paper reviews the research and development history and current status of representative adjuvants in approved prophylactic vaccines, expounds the benefits provided by adjuvants and the mechanisms, as well as the general principles and different characteristics followed by different types of adjuvants in vaccine development and application. From the perspectives of development and regulation,this paper puts forward relevant thoughts and suggestions on adjuvant type screening, vaccine antigen optimization, adjuvant and vaccine formulation research, etc., aiming to provide references for improving the safety, effectiveness, and stability in the research and development process of vaccines with adjuvants.
