Research progress on construction of animal models for transplanted cervical cancer
10.13200/j.cnki.cjb.004522
- VernacularTitle:移植性宫颈癌动物模型构建的研究进展
- Author:
WEI Mingjing
- Publication Type:Journal Article
- From:
Chinese Journal of Biologicals
2025;38(07):876-881
- CountryChina
- Language:Chinese
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Abstract:
Cervical cancer is a serious malignant tumor that poses a significant threat to women's health, and in low-income and developing countries with limited infrastructure, the incidence and mortality rates remain high. Transplanted animal models of cervical cancer are one of the tools for studying the prevention and treatment of this disease, which can effectively characterize the characteristics of the tumor. These models are mainly classified into cell line-derived xenograft(CDX) tumor models, patient-derived xenograft(PDX) models, and patient-derived organoids-based xenograft(PDOX) models. This review systematically summarizes the types, construction methods, and applications of different transplanted cervical cancer animal models, laying a foundation for the further exploration of the occurrence, development, and treatment of cervical cancer.
