Advances in research on antibacterial mechanisms of non-antibiotic drugs against drug-resistant Staphylococcus aureus
10.13200/j.cnki.cjb.004528
- VernacularTitle:非抗菌药物对耐药金黄色葡萄球菌抗菌机制的研究进展
- Author:
SUN Yingying
- Publication Type:Journal Article
- Keywords:
Non-antibiotic drugs;
Drug repurposing;
Drug-resistant Staphylococcus aureus;
Drug-resistant bacteria
- From:
Chinese Journal of Biologicals
2025;38(07):858-865
- CountryChina
- Language:Chinese
-
Abstract:
The proliferation of antibiotic-resistant Staphylococcus aureus poses an escalating threat to global public health.These superbugs have developed resistance to multiple antimicrobial agents, significantly increasing treatment complexity and costs. In the face of this challenge, the development of novel antimicrobial drugs is imperative, yet traditional research and development pathways are hindered by high costs and a lack of new targets. In recent years, researchers have pioneered an innovative approach: re-evaluating the antimicrobial potential of existing non-antibiotic drugs. This drug repurposing strategy leverages the known pharmacological properties of existing drugs, offering new perspectives for antimicrobial therapy. This paper reviews the mechanisms of action of 15 non-antibiotic drugs, including Diacerein and Niclosamide, in combating drug-resistant Staphylococcus aureus strains. This research not only provides new options for clinical practice but also paves innovative pathways for addressing bacterial resistance. Through interdisciplinary collaboration and innovative thinking, the battle against these multidrug-resistant pathogens is poised to achieve breakthrough progress.
