The relationship between TOMM40 gene polymorphism and inflammatory status and cognitive function in patients with vascular dementia
10.19845/j.cnki.zfysjjbzz.2025.0100
- VernacularTitle:TOMM40基因多态性与血管性痴呆患者炎症状态及认知功能的关系
- Author:
Yue MA
1
;
Peng ZHANG
2
;
Xiuyan ZHANG
1
Author Information
1. 黑龙江省医院神经内二科，黑龙江 哈尔滨 150000
2. 黑龙江省医院老年神经科，黑龙江 哈尔滨 150000
- Publication Type:Journal Article
- Keywords:
Translocase of outer mitochondrial membrane 40;
Gene polymorphism;
Vascular dementia;
Cognitive function;
Interleukin-10
- MeSH:
Interleukin-10
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(6):529-533
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between translocase of outer mitochondrial membrane 40（TOMM40）gene polymorphism and inflammatory status and cognitive function in patients with vascular dementia（VaD）. Methods From June 2020 to December 2022，48 patients with VaD and 40 age-matched control participants were enrolled. TOMM40_rs11556505 and IL-10-592 A/C_rs1800872 polymorphisms were measured. The cognitive function of the patients was evaluated by using the Repeatable Battery for the Assessment of Neuropsychological Status（RBANS）. Results The main effects of VaD were significant in all the analyses of the sub-scores and total score of RBANS（all P<0.001，all FDR<0.001）. TOMM40_rs11556505 polymorphism had a significant main effect on language score（F=4.524，P=0.034，Cohen f=0.08）. TOMM40×VaD had significant interaction effects on immediate memory（F=4.682，P=0.031，Cohen f=0.08）and language score（F=4.465，P=0.035，Cohen f=0.08）. The two-way multivariate analysis of covariance（IL-10×TOMM40）revealed significant interaction effects between their gene polymorphisms on visual space/structure（F=4.063，P=0.045，FDR=0.080，Cohen f=0.13），language（F=12.031，P<0.001，FDR=0.006，Cohen f=0.23），and delayed memory（F=5.118，P=0.025，FDR=0.075，Cohen f=0.23）in patients with VaD. Conclusion IL-10-592 A/C and TOMM40_rs11556505 gene polymorphisms have interaction effects on cognitive function，with their influence direction depending on each other's genotype.
- Full text:202507171348177588TOMM40基因多态性与血管性痴呆患者炎症状态及认知功能的关系.pdf
